Widespread amyloid aggregates formation by Zika virus proteins and peptides
Rajanish Giri,
Taniya Bhardwaj,
Shivani K. Kapuganti
et al.
Abstract:Viral pathogenesis typically involves numerous molecular mechanisms. Protein aggregation is a relatively unknown characteristic of viruses, despite the fact that viral proteins have been shown to form terminally misfolded forms. Zika virus (ZIKV) is a neurotropic one with the potential to cause neurodegeneration. Its protein amyloid aggregation may link the neurodegenerative component to the pathogenicity associated with the viral infection. Therefore, we investigated protein aggregation in the ZIKV proteome a… Show more
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