Widespread distribution of hepatitis E virus in plasma fractionation pools

Baylis, Sally A.; Koc, Özgür M; Nick, Sigrid; Blümel, Johannes

doi:10.1111/j.1423-0410.2011.01527.x

Cited by 64 publications

(70 citation statements)

References 5 publications

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“…The published reports of HEV infections by contaminated blood products (2,(17)(18)(19)(20) and the detection of HEV in plasma fractionation pools (23,24) and samples from blood donors (22,25,33,34) suggest that transfusion transmission of HEV is probably not uncommon. Many of the infections are subclinical (22,34), with infections being incorrectly diagnosed or undiagnosed due to the applied test regimen.…”

Section: Discussionmentioning

confidence: 99%

“…The transmission of hepatitis E infections by contaminated blood products has already been reported in Europe, Japan, and the United Kingdom (2,(17)(18)(19)(20)(21). The occurrence of autochthonous and asymptomatic infections in blood donors, as well as the detection of widespread distribution of HEV in plasma fractionation pools from North America, Europe, and southeast Asia, makes HEV a potential new hazardous bloodborne pathogen with respect to blood safety (2,(22)(23)(24)(25).…”

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confidence: 99%

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Comparison of Real-Time PCR and Antigen Assays for Detection of Hepatitis E Virus in Blood Donors

2014

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of Real-Time PCR and Antigen Assays for Detection of Hepatitis E Virus in Blood Donors

2014

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“…In großen Plasmapools (ca. 10.000 Spenden) wurden auch Belastungen von 10 3 ge/ml beobachtet [176,179]. …”

Section: Belastung Des Ausgangsmaterials Und Testmethodenunclassified

“…Asien konnten mit der PCR HEV-Genome nachgewiesen werden [179]. Acht von 75 Pools waren positiv für HEV-Sequenzen, wobei Pools europäischer bzw.…”

Section: Prävalenz Und Inzidenz Bei Spenderkollektivenunclassified

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Hepatitis-E-Virus

Gesundheit¹

2015

Bundesgesundheitsbl.

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Hepatitis E: Genotypes, strategies to prevent and manage, and the existing knowledge gaps

2021

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Hepatitis E virus (HEV) is considered an emergent source of viral hepatitis worldwide, with an increasing burden of jaundice, liver failure, extrahepatic illnesses, and deaths in developed countries. With the scarcity of data from efficient animal models, there are still open‐ended questions about designing new models to study pathogenesis, types, virology, and evolution of these viruses. With an emphasis on available data and updates, there is still enough information to understand the HEV life cycle, pathogen interaction with the host, and the valuation of the role of vaccine and new anti‐HEV therapies. However, the World Health Organization (WHO) and the European Association for the Study of the Liver (EASL) preferred to stress prevention and control measures of HEV infections in animals, zoonotic transmission, and foodborne transmission. It is being reviewed that with current knowledge on HEV and existing prevention tools, there is an excellent room for in‐depth information about the virus strains, their replication, pathogenicity, and virulence. The current knowledge set also has gaps regarding standardized and validated diagnostic tools, efficacy and safety of the vaccine, and extrahepatic manifestations specifically in pregnant females, immunocompromised patients, and others. This review highlights the areas for more research exploration, focusing on enlisted research questions based on HEV infection to endorse the need for significant improvement in the current set of knowledge for this public health problem.

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Widespread distribution of hepatitis E virus in plasma fractionation pools

Cited by 64 publications

References 5 publications

Comparison of Real-Time PCR and Antigen Assays for Detection of Hepatitis E Virus in Blood Donors

Comparison of Real-Time PCR and Antigen Assays for Detection of Hepatitis E Virus in Blood Donors

Hepatitis-E-Virus

Hepatitis E: Genotypes, strategies to prevent and manage, and the existing knowledge gaps

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