Widespread White Matter Aberrations Are Associated with Phonemic Verbal Fluency Impairment in Chronic Traumatic Brain Injury

Yamagata, Bun; Ueda, Ryo; Tasato, Kumiko; Aoki, Yuta; Hotta, Shogo; Hirano, Jinichi; Takamiya, Akihiro; Nakaaki, Shutaro; Tabuchi, Hajime; Mimura, Masaru

doi:10.1089/neu.2019.6751

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…Longterm cognitive deficits may be due to structural damage, neuronal loss, or white matter alterations [51][52][53] . There is a clear correlation between the degree of white matter damage and cognitive deficits in humans [54][55][56][57][58][59][60] , and repeated injuries exacerbate these changes 14,30,34,56,61 . It is assumed that particular deficits in executive function or slow processing are due to alterations in the dorsal lateral prefrontal cortex or white matter, respectively 62 .…”

Section: Discussionmentioning

confidence: 99%

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Pinkowski

Guerin

Zhang

et al. 2020

Neurobiology of Learning and Memory

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Section: Discussionmentioning

confidence: 99%

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Pinkowski

Guerin

Zhang

et al. 2020

Neurobiology of Learning and Memory

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“…Differences in DTI parameters between unsafe and safe drivers were analyzed in a voxel‐wise fashion using the Randomise function in FSL with 5000 permutations and age and sex as covariates 29 . Statistical significance was set at a family‐wise error rate ( α = 0.05)‐corrected threshold‐free cluster enhancement (TFCE) of p < 0.05, with a minimum cluster size of 10 voxels 30 …”

Section: Methodsmentioning

confidence: 99%

“… 29 Statistical significance was set at a family‐wise error rate ( α = 0.05)‐corrected threshold‐free cluster enhancement (TFCE) of p < 0.05, with a minimum cluster size of 10 voxels. 30 …”

Section: Methodsmentioning

confidence: 99%

White matter alterations in the dorsal attention network contribute to a high risk of unsafe driving in healthy older people

et al. 2022

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Aim: Healthy older drivers may be at high risk of fatal traffic accidents. Our recent study showed that volumetric alterations in gray matter in the brain regions within the dorsal attention network (DAN) were strongly related to the risk of unsafe driving in healthy older people. However, the relationship between white matter (WM) structural connectivity and driving ability in healthy older people is still unclear. Methods:We used diffusion tensor imaging to examine the association between microstructural alterations in the DAN and the risk of unsafe driving among healthy older people. We enrolled 32 healthy older individuals aged over 65 years and screened unsafe drivers using an on-road driving test. We then determined the pattern of WM aberrations in unsafe drivers using tract-based spatial statistics.Results: The analysis demonstrated that unsafe drivers had significantly higher axial diffusivity values in nine WM clusters compared with safe drivers. These results were primarily observed bilaterally in the dorsal superior longitudinal fasciculus, which is involved in the DAN. Furthermore, correlation analyses showed that higher axial diffusivity values in the superior longitudinal fasciculus were associated with lower Trail Making Test A scores within unsafe drivers. This result suggests that functionally, WM microstructural alterations in the DAN are associated with attention problems, which may contribute to the risk of unsafe driving among healthy older people. Conclusion: Our findings may elucidate the neurobiological mechanisms underlying the increased risk of unsafe driving in healthy older people, potentially facilitating the development of new interventions to prevent fatal accidents.

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Mediation of White Matter Alterations in the Association Between Ventricular Dilation and Cognitive Decline in Hydrocephalus Patients: An MRI Study

Xiao,

Gui,

Dai

et al. 2024

Magnetic Resonance Imaging

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BackgroundCognitive impairment is commonly observed in hydrocephalus patients. Ventricular enlargement compresses brain parenchyma, especially the white matter (WM).PurposeTo investigate whether the relationship between ventricular dilation and cognitive decline in hydrocephalus patients is mediated by WM alterations.Study TypeRetrospective.Population51 communicating hydrocephalus patients (median age, 54 years), 50 obstructive hydrocephalus patients (median age, 49 years), and 53 control subjects (median age, 50 years).Field Strength/SequenceDiffusion tensors imaging, 3D T1 BRAVO, 3D FIESTA, CUBE T2, and FLAIR sequences at 3T.AssessmentDTI parameters (skeletonized fractional anisotropy (FA), skeletonized mean diffusivity (MD), and peak width of skeletonized mean diffusivity p(PSMD)) were extracted using FSL software. Global, periventricular, and deep white matter hyperintensity (WMH) volumes, degree of ventricular enlargement (Evans index), and other conventional imaging markers (number of lacunes and perivascular spaces, intracranial and brain volume) were extracted using united imaging intelligence. Cognitive tests included Montreal cognitive assessment (MoCA), clock drawing test (CDT), and vocabulary fluency test (VFT).Statistical TestsMultivariable linear regression analysis, mediation analyses, and dominance analysis. P‐value <0.05 was considered significant.ResultsThe degree of ventricular dilation, DTI parameters, and cognitive function scores were interrelated. The skeletonized FA values (β = −0.0917, 95% confidence interval (CI): −0.205, −0.024) and normalized global WMH volume (β = −0.0635, 95% CI: −0.13, −0.0005) together mediated 37.2% of the association between Evans index and MoCA. A comparable causal pathway was found for periventricular WMHs but not for deep WMHs. Dominance analysis indicated skeletonized FA values had a greater impact on cognition than WMH volume. The skeletonized FA values also mediated the association between Evans index and CDT (β = −0.0897, 95% CI: −0.165, −0.026) and VFT (β = −0.1589, 95% CI: −0.27, −0.083).ConclusionWM alterations were causal mediators between ventricular dilation and cognitive decline in hydrocephalus patients.Evidence Level3.Technical EfficacyStage 3.

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Widespread White Matter Aberrations Are Associated with Phonemic Verbal Fluency Impairment in Chronic Traumatic Brain Injury

Cited by 7 publications

References 43 publications

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

White matter alterations in the dorsal attention network contribute to a high risk of unsafe driving in healthy older people

Mediation of White Matter Alterations in the Association Between Ventricular Dilation and Cognitive Decline in Hydrocephalus Patients: An MRI Study

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