Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Chen, Yi; Shui, Mingju; Yuan, Qin; Vong, Chi Teng; Yang, Zhengming; Chen, Zhejie; Wang, Shengpeng

doi:10.1016/j.jconrel.2023.05.007

Cited by 25 publications

(6 citation statements)

References 238 publications

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“…In the inflammatory pathological microenvironment, several kinds of immune cells such as neutrophils are highly infiltrated, which will lead to an increase in the content of ROS in the intestinal tract . ROS can destroy the activity of probiotics, cause intestinal flora disorder, and further disrupt the colonization of probiotics in the gut. , Therefore, we evaluated the resistance of coated probiotics to ROS in the hydrogen peroxide environment in vitro . The cell viability after H 2 O 2 stimulation was also detected by the CCK-8 assay.…”

Section: Resultsmentioning

confidence: 99%

“…4 ROS can destroy the activity of probiotics, cause intestinal flora disorder, and further disrupt the colonization of probiotics in the gut. 34,35 Therefore, we evaluated the resistance of coated probiotics to ROS in the hydrogen peroxide environment in vitro. The cell viability after H 2 O 2 stimulation was also detected by the CCK-8 assay.…”

Section: Resistance Of Modified Ecn Against Gastrointestinal Assaultsmentioning

confidence: 99%

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Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Hu,

Li,

Wang

et al. 2024

ACS Nano

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Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of the broad bioactivity and high compatibility of polyphenols, there is considerable interest in developing a polyphenol-based collaborative platform to remodel the IBD microenvironment and regulate microbiota. Here, we demonstrated the coordination assembly of nanostructured polyphenols to modify probiotics and simultaneously deliver drugs for IBD treatment. Inspired by the distinctive structure of tannic acid (TA), we fabricated nanostructured pBDT-TA by using a self-polymerizable aromatic dithiol (BDT) and TA, which exhibited excellent antioxidant and anti-inflammatory capability in vitro. We thus coated pBDT-TA and sodium alginate (SA) to the surface of Escherichia coli Nissle 1917 layer by layer to construct the collaborative platform EcN@SA-pBDT-TA. The modified probiotics showed improved resistance to oxidative and inflammatory stress, which resulted in superior colon accumulation and retention in IBD model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate sodium (DSS)-induced colitis by controlling the inflammatory response, repairing intestinal barriers, and modulating gut microbiota. Importantly, EcN@SA-pBDT-TA-mediated IBD drug delivery could achieve an improved therapeutic effect in DSS model mice. Given the availability and functionality of polyphenol and prebiotics, we expected that nanostructured polyphenol-modified probiotics provided a solution to develop a collaborative platform for IBD treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resistance Of Modified Ecn Against Gastrointestinal Assaultsmentioning

confidence: 99%

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Hu,

Li,

Wang

et al. 2024

ACS Nano

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“…Similar to other chronic local inflammatory diseases, UC involves long‐term pathological accumulation of ROS; thus, the effective removal of ROS can protect colon cells from apoptosis and complex chronic inflammatory processes. [ 35 ] In early studies, BSNM with prominent DPPH radical scavenging ability (Figure S3, Supporting Information) and inconspicuous cytotoxicity (Figure S4, Supporting Information) could be effectively uptake by Raw264.7 and NCM460 cells in vitro (Figure S5, Supporting Information). In the present study, the anti‐oxidant and anti‐inflammatory effects of BSNM were determined in lipopolysaccharide (LPS)‐stimulated Raw264.7 and NCM460 cells.…”

Section: Resultsmentioning

confidence: 99%

Oral Delivery of Transformable Bilirubin Self‐Assembled System for Targeted Therapy of Colitis

Chen,

Hao

et al. 2023

Adv Healthcare Materials

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Ulcerative colitis (UC) is a high incidence disease worldwide and clinically presents as relapsing and incurable inflammation of the colon. Bilirubin (BR), a natural antioxidant with significant anti‐colitic effects, is utilized in preclinical studies as an intestinal disease therapy. Due to their water‐insolubility, the design of BR‐based agents usually involves complicated chemosynthetic processes, introducing various uncertainties in BR development. After screening numerous materials, it is identified that chondroitin sulfate can efficiently mediate the construction of BR self‐assembled nanomedicine (BSNM) via intermolecular hydrogen bonds between dense sulfate and carboxyl of chondroitin sulfate and imino groups of BR. BSNM exhibits pH sensitivity and reactive oxygen species responsiveness, enabling targeted delivery to the colon. After oral administration, BSNM significantly inhibits colonic fibrosis and apoptosis of colon and goblet cells; it also reduces the expression of inflammatory cytokines. Moreover, BSNM maintains the normal level of zonula occludens‐1 and occludin to sustain the integrity of intestinal barrier, regulates the macrophage polarization from M1 to M2 type, and promotes the ecological recovery of intestinal flora. Collectively, the work provides a colon‐targeted and transformable BSNM that is simple to prepare and is useful as an efficient targeted UC therapy.

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“…The abnormal physiology was observed in colon in ulcerative colitis patients, including decreased pH and high concentration of ROS. , In addition, folate receptor was overexpressed in colonic tissues with IBD, which provides an opportunity for targeting treatment of IBD by FA-modified nanotherapeutics . Herein, an FA-modified pH/ROS dual-responsive nanoplatform was employed to deliver CsA to inflammatory colonic tissues for the targeted treatment of colitis in mice.…”

Section: Discussionmentioning

confidence: 99%

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

Li,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

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Inflammatory bowel disease (IBD) is a frequently occurring disease that seriously influences the patient’s quality of life. To decrease adverse effects and improve efficacy of therapeutics, nanomedicines have been widely used to treat IBD. However, how to thoroughly release payloads under an inflammatory microenvironment and synergistic therapy of IBD need to be further investigated. To address this issue, cyclosporine A (CsA)-loaded, folic acid (FA)-modified, pH and reactive oxygen species (ROS) dual-responsive nanoparticles (FA-CsA NPs) were fabricated using pH/ROS-responsive material as carrier. The prepared FA-CsA NPs had spherical shape and uniform size distribution and could smartly release their payloads under acid and/or ROS microenvironment. In vitro experiments demonstrated that FA-CsA NPs can be effectively internalized by activated macrophages, and the internalized NPs could down-regulate the expression of proinflammatory cytokines compared to free drug or nontargeted NPs. In vivo experiments verified that FA-CsA NPs significantly accumulated at inflammatory colon tissues and the accumulated NPs obviously improved the symptoms of colitis in mice without obvious adverse effects. In conclusion, our results provided a candidate for the targeted treatment of IBD.

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Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Cited by 25 publications

References 238 publications

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Oral Delivery of Transformable Bilirubin Self‐Assembled System for Targeted Therapy of Colitis

Cyclosporine A-Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice

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