Wild animals in studies on vanadium bioaccumulation - Potential animal models of environmental vanadium contamination: A comprehensive overview with a Polish accent

Ścibior, Agnieszka; Wnuk, Ewa; Gołębiowska, Dorota

doi:10.1016/j.scitotenv.2021.147205

Cited by 20 publications

(14 citation statements)

References 150 publications

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“…Vanadium (V) is an essential element for some living organisms, but its role as a micronutrient has not yet been clarified. Moreover, some aspects of its role in cell metabolism, the toxicological implications and the therapeutic applications remain unknown [ 13 , 14 , 15 ]. Clarifying the metabolic implication of V in diabetes mellitus has received attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.

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Section: Introductionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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“…Vanadium is needed for vanadium‐flow batteries, potentially on a very large scale (Colthorpe, 2021 ; Gencten & Sahin, 2020 ; Zhang et al., 2019 ), in addition to the established demands for high‐strength steel and electronics. However, there is an increasing awareness of the possible health hazards of high levels of vanadium in the environment (Amuah et al., 2021 ; Mitchell et al., 2011 ; Vasseghian et al., 2021 ; Ścibior et al., 2021 ). Excessive amounts of vanadium in the human body can affect the digestive system, the urinary tract, and the reproductive system and for example, cause anemia, kidney disease, asthma, dermatitis, and rhinitis (Jayawardana et al., 2015 ; Wilk et al., 2017 ; Yang et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Vanadium for Green Energy: Increasing Demand but With Health Implications in Volcanic Terrains

Parnell

2022

GeoHealth

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The transition to a clean energy future may require a very substantial increase in resources of vanadium. This trend brings into focus the potential health issues related to vanadium in the environment. Most vanadium enters the Earth's crust through volcanic rocks; hence, vanadium levels in groundwaters in volcanic aquifers are higher than in other aquifers and can exceed local guidance limits. The biggest accumulation of volcanogenic sediment on the planet is downwind of the Andes and makes up much of Argentina. Consequently, groundwaters in Argentina have the highest vanadium contents and constitute a global vanadium anomaly. The high vanadium contents have given rise to health concerns. Vanadium could be extracted during remediation of domestic and other groundwater, and although the resultant resource is limited, it would be gained using low‐energy technology.

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Section: Introductionmentioning

confidence: 99%

“…Vanadium (V) is a transition element released into the environment from both natural sources and anthropogenic activity [ 1 ]. It may accumulate in the environmental media [ 2 , 3 ] and in tissues and organs of living organisms [ 1 ]. At certain levels, V is toxic and can lead to serious health problems, summarized in our previous reports [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…It may accumulate in the environmental media [ 2 , 3 ] and in tissues and organs of living organisms [ 1 ]. At certain levels, V is toxic and can lead to serious health problems, summarized in our previous reports [ 1 , 4 ]. Bearing these facts in mind, there is a need for detailed and systemic investigations to evaluate the toxicity of V and possible toxic effects caused by its chronic treatment and to recognize the consequences of possible interactions of V with elements having antioxidant properties, including magnesium (Mg), which is important in view of the strong prooxidant potential of V.…”

Section: Introductionmentioning

confidence: 99%

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Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2‐Keap1 System

Ścibior

Wojda

Wnuk

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) is a mechanism underlying metal-induced toxicity. As a redox-active element, vanadium (V) can act as a strong prooxidant and generate OS at certain levels. It can also attenuate the antioxidant barrier and intensify lipid peroxidation (LPO). The prooxidant potential of V reflected in enhanced LPO, demonstrated by us previously in the rat liver, prompted us to analyze the response of the nuclear factor erythroid-derived 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2-Keap1) system involved in cellular regulation of OS to administration of sodium metavanadate (SMV, 0.125 mg V/mL) and/or magnesium sulfate (MS, 0.06 mg Mg/mL). The levels of some Nrf2-dependent cytoprotective and detoxifying proteins, i.e., glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), glutamate cysteine ligase catalytic subunit (GCLC), glutathione synthetase (GSS), NAD(P) H dehydrogenase quinone 1 (NQO1), UDP-glucumno-syltransferase 1 (UGT1), and heme oxygenase 1 (HO-1); glutathione (GSH); metallothionein (MT1); and glutamate-cysteine ligase (GCL) mRNA were measured. We also focused on the V-Mg interactive effects and trends toward interactive action as well as relationships between the examined indices. The elevated levels of Nrf2, GCL mRNA, and GCL catalytic subunit (GCLC) confirm OS in response to SMV and point to the capacity to synthesize GSH. The results also suggest a limitation of the second step in GSH synthesis reflected by the unchanged glutathione synthetase (GSS) and GSH levels. The positive correlations between certain cytoprotective/detoxifying proteins (which showed increasing trends during the SMV and/or MS administration, compared to the control) and between them and malondialdehyde (MDA), the hepatic V concentration/total content, and/or V dose (discussed by us previously) point to cooperation between the components of antioxidant defense in the conditions of the hepatic V accumulation and SMV-induced LPO intensification. The V-Mg interactive effect and trend are involved in changes in Nrf2 and UGT1, respectively. The p62 protein has to be determined in the context of potential inhibition of degradation of Keap1, which showed a visible upward trend, in comparison with the control. The impact of Mg on MT1 deserves further exploration.

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Wild animals in studies on vanadium bioaccumulation - Potential animal models of environmental vanadium contamination: A comprehensive overview with a Polish accent

Cited by 20 publications

References 150 publications

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Vanadium for Green Energy: Increasing Demand but With Health Implications in Volcanic Terrains

Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2‐Keap1 System

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