Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

Jia, Zaixing; Gong, Wenping

doi:10.3346/jkms.2021.36.e124

Cited by 81 publications

(82 citation statements)

References 20 publications

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“…Of note, a direct comparison of viral loads in vaccinated vs non-vaccinated individuals was not reported. Interestingly, a very recent review concluded that after vaccination with the mRNA-1273 and BNT162b2 vaccines, their neutralization activity decreased slightly against SARS-CoV-2 variants carrying the E484K (like variant B.1.1.7) or N501Y or the K417N-E484K-N501Y combination of mutations (like variant B.1.1351) [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers

Ιωάννου

Karakonstantis

Astrinaki

et al. 2021

Infectious Diseases

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Background Vaccination against COVID-19 is among the most effective measures to stop the spread of the disease. However, acceptance of vaccination against COVID-19 among HCWs has not been universal and emergence of new variants with increased transmissibility, reduced neutralization by BNT162b2 vaccine-elicited sera and ability to cause breakthrough infections in vaccinated individuals is concerning. The aim of this study was to compare viral load, clinical presentation at diagnosis and type of exposure among vaccinated (with BNT162b2) and non-vaccinated healthcare workers (HCWs). Methods Prospective cohort of HWCs diagnosed with COVID-19 by nasopharyngeal PCR from 4 January to 14 April. Viral loads were expressed by the cycle threshold (Ct) in PCR. Results During the study period 55 HCWs were found positive for SARS-CoV-2, most of whom (44/55) were identified from March 28 to April 14 during an in-hospital COVID-19 outbreak. Of the 55 HCWs, 21 were fully vaccinated and another three had received one dose. Most cases (54/55) were due to variant B.1.1.7. Vaccinated and unvaccinated HCWs did not differ significantly in regards to age, gender, site of acquisition, presence of symptoms at diagnosis and viral load. Conclusions This study found a similar viral load in vaccinated and non-vaccinated HCWs infected by SARS-CoV-2 variant B.1.1.7, suggesting potentially reduced efficacy of BNT162b2 in preventing transmission of B.1.1.7.

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Section: Discussionmentioning

confidence: 99%

Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers

Ιωάννου

Karakonstantis

Astrinaki

et al. 2021

Infectious Diseases

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“…The infectivity of coronaviruses depends on the spike protein which facilitates the viral attachment and entry to the host cells [42]. However, there is great variability in the structure of the spike proteins among coronavirus species, more so, the several variants of the SARS-COV-2 itself due to genetic mutations [43,44]. Conversely, helicase nsp13 is a non-structural protein highly conserved among all coronavirus species [44].…”

Section: Discussionmentioning

confidence: 99%

Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2

et al. 2021

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In response to the ongoing COVID-19 pandemic, the global effort to develop high efficacy countermeasures to control the infection are being conducted at full swing. While the efficacy of vaccines and coronavirus drugs are being tested, the microbiome approach represents an alternative pathophysiology-based approach to prevent the severity of the infection. In the current study, we evaluated the action of a novel probiotic Lactobacillus plantarum Probio-88 against SARS-COV-2 replication and immune regulation using an in vitro and in silico study. The results showed that extract from this strain (P88-CFS) significantly inhibited the replication of SARS-COV-2 and the production of reactive oxygen species (ROS) levels. Furthermore, compared with infected cells, P88-CFS treated cells showed a significant reduction in inflammatory markers such as IFN-α, IFN-β, and IL-6. Using an in silico molecular docking approach, it was postulated that the antiviral activity of L. plantarum Probio-88 was derived from plantaricin E (PlnE) and F (PlnF). The high binding affinity and formation of hydrogen bonding indicated that the association of PlnE and PlnF on SARS-COV-2 helicase might serve as a blocker by preventing the binding of ss-RNA during the replication of the virus. In conclusion, our study substantiated that P88-CFS could be used as an integrative therapeutic approach along with vaccine to contain the spread of the highly infectious pathogen and possibly its variants.

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“…Since December 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread worldwide, triggering one of the most challenging pandemics so far [ 1 , 2 ]. In the last months, several variants of this virus have been reported [ 3 , 4 ], some of which have raised additional concern due to increased transmissibility [ 5 ], higher rates of mortality [ 6 ], escape from immune system response [ 7 ], altered vaccine effectiveness [ 7 , 8 ] or failure in diagnosis tests [ 9 ]. These variants of concern (VOC) carry several genetic mutations, most of which are at the level of the spike (S) protein receptor-binding domain (RBD), which plays a key role in triggering virus entry into the cell, by binding to the cell host angiotensin-converting enzyme 2 (ACE-2) receptor.…”

Section: Introductionmentioning

confidence: 99%

First Detection of SARS-CoV-2 B.1.1.7 Variant of Concern in an Asymptomatic Dog in Spain

Barroso-Arévalo

Rivera

Domı́nguez

et al. 2021

Viruses

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Natural SARS-CoV-2 infection in pets has been widely documented during the last year. Although the majority of reports suggested that dogs’ susceptibility to the infection is low, little is known about viral pathogenicity and transmissibility in the case of variants of concern, such as B.1.1.7 in this species. Here, as part of a large-scale study on SARS-CoV-2 prevalence in pets in Spain, we have detected the B.1.1.7 variant of concern (VOC) in a dog whose owners were infected with SARS-CoV-2. The animal did not present any symptoms, but viral loads were high in the nasal and rectal swabs. In addition, viral isolation was possible from both swabs, demonstrating that the dog was shedding infectious virus. Seroconversion occurred 23 days after the first sampling. This study documents the first detection of B.1.1.7 VOC in a dog in Spain and emphasizes the importance of performing active surveillance and genomic investigation on infected animals.

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Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

Cited by 81 publications

References 20 publications

Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers

Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers

Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2

First Detection of SARS-CoV-2 B.1.1.7 Variant of Concern in an Asymptomatic Dog in Spain

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