The anti‐corruption capabilities of e‐procurement have not gotten any attention in Ghana, although the success factors of e‐procurement adoption have been thoroughly researched. The study's main objective is to assess how e‐procurement may reduce procurement fraud and corruption in Ghanaian mining enterprises. A self‐administered questionnaire was used to gather information on the extent to which e‐procurement anti‐corruption factors outlined in the literature reduced procurement fraud and corruption in Ghanaian mining firms from the perspectives of sector practitioners. The data was then analyzed using factor analysis. The study revealed the breaking of the monopoly of power, transparency and accountability, and breaking of information asymmetry, as e‐procurement anti‐corruption variables that combat procurement fraud and corruption in the mining companies. The most effective e‐procurement factor for preventing procurement fraud and corruption is the breaking of the monopoly of power, followed by transparency and accountability, and the least is the breaking of information asymmetry. To reduce procurement fraud and corruption, the government and organizations that manage procurement activities will now have a better understanding of the e‐procurement anti‐corruption activities and be guided as such.