Wilms’ Tumor in Children: An Overview

Varan, Ali

doi:10.1159/000113012

Cited by 44 publications

(42 citation statements)

References 119 publications

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“…Wilms tumor is the most prevalent renal malignant tumor in children. But fortunately, it is also one of the most treatment-responsive tumors (reviewed in [88]). Thus, several therapeutic options are available to treat Wilms tumor successfully.…”

Section: S1p In Renal Disease Modelsmentioning

confidence: 99%

Sphingosine 1-Phosphate in Renal Diseases

Koch

Pfeilschifter

Huwiler

2013

Cell Physiol Biochem

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Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.

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Section: S1p In Renal Disease Modelsmentioning

confidence: 99%

Sphingosine 1-Phosphate in Renal Diseases

Koch

Pfeilschifter

Huwiler

2013

Cell Physiol Biochem

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“…Kaval trombüs cerrahi öncesinde bilinmezse nefrektomi sırasında emboli ve mortaliteye neden olabilir (2) bun farklı tedavi yaklaşımı bulunmaktadır. Bu gruplar, Kuzey Amerika ülkelerini kapsayan Ulusal Wilms Tümörü Çalışma Grubu (National Wilms' Tumor Study Group (NWTSG) günümüzde Children's Oncology Group (COG)'un bir parçasıdır) ile Avrupa'da Société Internationale d'Oncologie Pédiatrique (SIOP)'dir (2,3) . Ülkemizde ise olgular Türk Pediatrik Onkoloji Grubu (TPOG) protokolüne göre sağaltıl-maktadır (4) .…”

Section: Wi̇lms Tümörüunclassified

Surgical principles in pediatric oncology

Bayhan¹,

Varan²,

Büyükpamukçu³

2016

tcdd

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ÖzÇocukluk çağı kanserlerine multidisipliner yaklaşımda cerrahi önemli bir yere sahiptir. Cerrahi Pediatrik onkolojide tanı ve tedavi aşamasında olmazsa olmazlardan biri çocuk cerrahisidir. Multidisipliner çalışmada ekibin bir parçası da cerrahtır. Tü-mör rezeksiyonunun derecesi, doğru evrelendirme, yaşam oranları ve morbidite üzerinde doğrudan etkilidir. Biyopsi ve çıkartımın derecesine cerrah karar vermektedir.Tanıda tümör tipine ve yerleşimine göre biyopsi, eksizyon veya tam çıkartım yapılmaktadır. Ayrıntıları tümör gruplarına göre aşağıda incelenecektir. Tanı açısından dikkat edilmesi gereken noktalardan biri alınan her örneğin atılmaksızın, patoloji sonucu öğ-renilene kadar takip edilmesidir. Apendiks bile atıl-mamalı, apendikste karsinoid, non-Hodgkin lenfoma tanıları ile karşılaşılabileceği unutulmamalıdır. Diğer bir önemli nokta tanıda gecikmedir. Çocukluk çağı tümörleri çoğu hızlı ilerleyebilen tümörlerdir. O nedenle günler içinde sonuç öğrenilmeli, tanı koyma süresi bir haftadan uzun olmamalıdır. Süre uzadıkça geri dönülmez karmaşalar ve sağaltımı olası olmayan ileri evre hastalıkla ve hatta ölümle sonuçlanabilmek-tedir. WİLMS TÜMÖRÜBöbrek tümörleri çocukluk çağı kanserlerinin %6'sını oluşturur ve bu tümörler içinde en sık görülen Wilms tümörüdür (%92). Wilms tümörü tanısı hastaların %78'inde 1-5 yaşları arasında konur. Hastaların %5'inde tümör bilateral olabilir (1) . Ender olarak tümör yırtılması ve kanama akut karın tablosuna yol açabilir. Wilms tümörü renal venden inferior vena kava ve sağ atriyuma, aşağıda ise üretere, mesaneye uzanabilir. En sık metastaz yeri akciğer ve karaciğerdir. Wilms tümörlerinin başvuru anında %4'ünde inferior vena kava veya atriyuma, %11'inde renal vene tümör uzanımı bulunabilir. Kaval trombüs cerrahi öncesinde bilinmezse nefrektomi sırasında emboli ve mortaliteye neden olabilir (2) . Genel sağkalım oranları 1900'lerde %5'ken, günümüzde %90'ın üzerine çıkmıştır.Wilms tümörü güncel tedavisinde iki uluslararası gru-

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“…This assertion can be corroborated by studies done in the sub-Saharan Africa by Ekense et al [2,3] which showed that Wilms' tumour is the most common childhood malignancy in Sub-Saharan Africa. Despite being a malignant tumour, a survival rate of over 90% is now seen today (compared to 30% in the thirties) and this is an evidence of the success of collaborative trials and the use of multimodal therapy [4][5][6]. Generally, childhood renal tumours are largely of embryonic origin, with rapidity of growth and a better response to therapy [1].…”

Section: Introductionmentioning

confidence: 99%

“…Generally, childhood renal tumours are largely of embryonic origin, with rapidity of growth and a better response to therapy [1]. Black children have a 2.5 times increased incidence over their white counterparts and the sex ratio is close to 1 [4]. Wilms' tumour is also associated with a number of recognised syndromes including WAGR, Beckwith-Wiedemann and Denys-Drash syndromes [1].…”

Section: Introductionmentioning

confidence: 99%

Morphological Features of Wilms’ Tumour in a Tertiary Health Care Institution: Our Findings

Soyemi¹,

Osuoji²,

Fa³

et al. 2013

J Clin Exp Pathol

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Nephroblastoma or Wilms' tumour is the most common primary renal malignancy of childhood. Despite being a malignant tumour, a survival rate of over 90% is now seen today (compared to 30% in the thirties) and this resulted from the success of collaborative trials and the use of multimodal therapy. Black children have a 2.5 times increased incidence over their white counterparts and the sex ratio is approximately 1.0. It is also associated with a number of recognised syndromes. The most important prognostic indicators for Wilms' tumour are the histological subtype and the stage at presentation. Although, studies have been carried out on this tumour focussing on the clinical aspect, it is worthy of note that very little study has been done on the morphological features of this tumour in this centre and the country at large. The purpose of this study is therefore to look at the morphological patterns of Wilms' tumour seen in this centre and if possible determine whether a relationship exists between the size, position of the tumour and the histological subtype, and finally, if a particular histological subtype is age-related. Patients and method:This is a retrospective study of the cases of Wilms' tumour seen in the division of paediatric surgery in our tertiary health care institution over a 5-year period i.e. (from Jan 2008 to Dec 2012). The nephrectomy samples of these patients were sent to the department of pathology and forensic medicine in the same institution. During grossing of the samples, adequate attention was paid to any obvious degenerative changes such as haemorrhage and necrosis. Where these changes were seen, they were recorded. The tumour sizes in the largest diameter and weights were also recorded. This was followed by histopathological reports which not only included the diagnosis, but also the histological types. These were all recorded in a pre-designed data form. The age at presentation in months and sex were also recorded in the form. All these were analysed using the statistical package for social science (SPSS) Software version 17.Results: In this study, 44 patients had Wilms' tumour with males representing 26 (59.1%) while females accounted for 18 (40.9%) and a male to female ratio was 1.4:1. The ages of the patients ranged from 10 months to 8 years with mean age value of 4 ± 2.91. The mode as well as the median age was 3 years. 24 (54.5%) of the tumours were located on the left position while 20 (45.5%) were seen on the right side. Most of the tumours weighed between 501-1000 grams representing (40.9%). In terms of tumour volume, majority measured between 1001-2000 cm 3 accounting for (40.9%). Necrosis was observed in 95.5% of the cases. It is also worthy of note that all the tumours had areas of haemorrhage grossly, and 100% exhibiting triphasic histological pattern. This characterizes the classical WT. Bilateral or Synchronous tumour was not seen in this study. Conclusion:The predominant histological pattern of Wilms' tumour in this centre is the triphasic pattern representing th...

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Wilms’ Tumor in Children: An Overview

Cited by 44 publications

References 119 publications

Sphingosine 1-Phosphate in Renal Diseases

Sphingosine 1-Phosphate in Renal Diseases

Surgical principles in pediatric oncology

Morphological Features of Wilms’ Tumour in a Tertiary Health Care Institution: Our Findings

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