Wilms' Tumor Protein 1 and Enzymatic Oxidation of 5-Methylcytosine in Brain Tumors: Potential Perspectives

Ramsawhook, Ashley; Ruzov, Alexey; Coyle, Beth

doi:10.3389/fcell.2018.00026

Cited by 7 publications

(1 citation statement)

References 126 publications

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“…5mC can be recognized and oxidized to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine by Ten-Eleven translocation (TET) enzymes[ 132 , 133 ]. One of the transcription factors that directly interacts with TET proteins is Wilms’ tumor protein 1 (WT1): A master regulator essential for urogenital, epicardium, and kidney development that can act as a tumor suppressor or oncoprotein in multiple tumors[ 134 , 135 ]. Initially cloned as a suppressor of Wilms’ tumor, WT1 is now considered to be an oncoprotein in hematologic malignancies and a variety of solid tumors, as well as the protein with the highest potential for cancer immunotherapy[ 136 - 138 ].…”

Section: Genes With Confirmed Role In Glioblastoma Stemnessmentioning

confidence: 99%

Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations

Kałuzińska¹,

Kołat²,

Kośla³

et al. 2023

World J Stem Cells

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Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness, the latter is one responsible for potentiating the resistance to treatment, inter alia due to increased invasiveness. In recent years, glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements, whereas the impact of the cytoskeleton on invasiveness is well known. Although non-stem glioblastoma cells are less invasive than glioblastoma stem cells (GSCs), these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core cells. This suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism, as they may provide new invasion-related insights. Previously, we proved that interplay between metabolism and cytoskeleton existed in glioblastoma. Despite searching for cytoskeleton-related processes in which the investigated genes might have been involved, not only did we stumble across the relation to metabolism but also reported genes that were found to be implicated in stemness. Thus, dedicated research on these genes in GSCs seems justifiable and might reveal novel directions and/or biomarkers that could be utilized in the future. Herein, we review the previously identified cytoskeleton/metabolism-related genes through the prism of glioblastoma stemness.

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