2018
DOI: 10.1016/j.gene.2018.06.078
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WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions

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Cited by 16 publications
(11 citation statements)
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“…S7H,I). Gryaznova et al have reported that WIP also localizes on RAB-4-positive endosomes (Gryaznova et al, 2018). Taken together, these results support that WIP-1 and DBN-1 do not play a profound role during the post-endocytic recycling or degradation pathway.…”
Section: Actin Assembly Cooperate With Dyn-1 For the Scission Of Ccpssupporting
confidence: 62%
See 1 more Smart Citation
“…S7H,I). Gryaznova et al have reported that WIP also localizes on RAB-4-positive endosomes (Gryaznova et al, 2018). Taken together, these results support that WIP-1 and DBN-1 do not play a profound role during the post-endocytic recycling or degradation pathway.…”
Section: Actin Assembly Cooperate With Dyn-1 For the Scission Of Ccpssupporting
confidence: 62%
“…To our surprise, the wip-1(ok2435)-induced aberrant membranous tubules contained both the CIE cargo hTAC and the CDE cargoes hTfR and MIG-14, and were capped by the CCPs at the tubular tips. Considering that WIP-1 and DBN-1 localize mainly at the CCPs and early endosomes, but not recycling endosomes and late endosomes (Gryaznova et al, 2015;Gryaznova et al, 2018;He et al, 2015), we inferred from the assay of Rhod-Dex staining that these membranous tubules are surface-connected scission-defective endocytic intermediates. However, we cannot exclude other possibilities, such as the F-actin dynamic assembly regulated by WIP-1 and DBN-1 at the early endosomes having an effect on the post-endocytic protein sorting or loss of WIP-1 or DBN-1 resulting in shunting of the CDE cargoes into RME-1-associated tubular subplasmalemma recycling endosomes as the CIE cargoes.…”
Section: Discussionmentioning
confidence: 99%
“…Both Rabaptin-5 and KIF16B coordinate Rab5 and Rab4 for efficient vesicle recycling (Hoepfner et al, 2005;Pagano et al, 2004;Stenmark et al, 1995). Recently, ITSN1-S has been reported to localize to Rab4-positive vesicles (Gryaznova et al, 2018) and to interact with DENND2B, an exchange factor for Rab13 involved in EGF receptor recycling (Ioannou et al, 2017). ITSN1 knock-out mice showed only minor (Yu et al, 2008) or no defects (Sakaba et al, 2013) in CME-dependent synaptic vesicle recycling in neurons, but neurons have enlarged EEA1-endosomes (Yu et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…21 The lack of intracellular DNA caused by ITSN1 knockout alters the signal balance of Smad2/3-ERK1/2 downstream of transferring growth factor receptor I, which causes the proliferation and neovascularization of pulmonary endothelial cells. 21,22 Thus, we decided to investigate the role of ITSN in breast carcinoma. Our results showed that ITSN1 had no connection with poor survival (Figure 6), which could be caused by small sample size.…”
Section: Discussionmentioning
confidence: 99%