Wireless pH‐motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation

Camilleri, Michael; Thorne, Nyree; Ringel, Yehuda; Hasler, William L.; Kuo, Braden; Esfandyari, Tuba; Gupta, Alisha; Scott, S. M.; McCallum, Richard W.; Parkman, Henry P.; Soffer, Edy E.; Wilding, Gregory E.; Semler, John R.; Rao, Satish S.C.

doi:10.1111/j.1365-2982.2010.01517.x

Cited by 181 publications

(146 citation statements)

References 39 publications

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“…Colonic transit time can be measured by obtaining abdominal radiographs after patients ingest radio-opaque markers, 56 a wireless motility capsule (WMC), 57,58 or by scintigraphy. 59 The WMC and scintigraphy can also measure gastric emptying and small intestinal transit, which may also be delayed in constipated patients.…”

Section: Colonic Transit Studymentioning

confidence: 99%

Diagnosis and Treatment of Dyssynergic Defecation

Rao

Patcharatrakul

2016

J Neurogastroenterol Motil

195

149

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Dyssynergic defecation is common and affects up to one half of patients with chronic constipation. This acquired behavioral problem is due to the inability to coordinate the abdominal and pelvic floor muscles to evacuate stools. A detailed history, prospective stool diaries, and a careful digital rectal examination will not only identify the nature of bowel dysfunction, but also raise the index of suspicion for this evacuation disorder. Anorectal physiology tests and balloon expulsion test are essential for a diagnosis. Newer techniques such as high-resolution manometry and magnetic resonance defecography can provide mechanistic insights. Recently, randomized controlled trials have shown that biofeedback therapy is more effective than laxatives and other modalities, both in the short term and long term, without side effects. Also, symptom improvements correlated with changes in underlying pathophysiology. Biofeedback therapy has been recommended as the first-line of treatment for dyssynergic defecation. Here, we provide an overview of the burden of illness and pathophysiology of dyssynergic defecation, and how to diagnose and treat this condition with biofeedback therapy.

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Section: Colonic Transit Studymentioning

confidence: 99%

Diagnosis and Treatment of Dyssynergic Defecation

Rao

Patcharatrakul

2016

J Neurogastroenterol Motil

195

149

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“…According to recent studies, there are relatively good correlations among these tests. [6][7][8] A colon transit time (CTT) test using radio-opaque markers (CTTRM) is regarded as the gold standard for evaluating colonic motility. This test classifies constipation into three subtypes, which are then used to determine treatment.…”

Section: Introductionmentioning

confidence: 99%

Value of 24-hour Delayed Film of Barium Enema for Evaluation of Colon Transit Function in Young Children with Constipation

Yoo

Son

Park

et al. 2016

J Neurogastroenterol Motil

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Background/AimsA colon transit time test using radio-opaque markers (CTTRM) is considered the gold standard for evaluating colon transit function. A 24-hour delayed film of barium enema (BE) has been used as a supplementary method in structural evaluations. The aim of this study was to evaluate the utility of a 24-hour delayed BE film for assessing colon transit function in young children with constipation. MethodsIn total, 93 children with constipation who performed both single-contrast BE and CTTRM were enrolled in this study. Of these, the data from 70 children were analyzed (males 33, females 37; mean age [range], 5.63 ± 2.94 [2-14] years). The basic principle of the study is "velocity = distance/time". Time values were identified in both studies, and the colon length and distance of barium movement were measured on the 24-hour delayed BE film. Thus, colon transit velocity values could be calculated using both methods. The correlation between colon transit velocity using a 24-hour delayed BE film versus CTTRM was analyzed statistically. ResultsMedian value (interquartile range) of colon transit velocity using CTTRM was 1.57 (1.07-2.89) cm/hr, and that using BE of that was 1.58 (0.94-2.07) cm/hr. The Spearman correlation coefficient was 0.438 (P < 0.001) for the overall group. The correlation was strongest in children younger than 4 years (r = 0.537, P = 0.032). ConclusionsAlthough the correlation between BE and CTTRM was not very strong, the 24-hour delayed BE film could provide broad information about colon transit function in young children, especially those under 4 years who usually cannot undergo CTTRM.

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“…27,28,64,65 It is indicated for detection of generalized dysmotility or as part of evaluation of WGTT.…”

Section: Wireless Motility Capsulementioning

confidence: 99%

Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies

Rao¹,

Camilleri²,

Hasler³

et al. 2010

Neurogastroenterology &Amp; Motility

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326

296

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Background Disorders of gastrointestinal (GI) transit and motility are common, and cause either delayed or accelerated transit through the stomach, small intestine or colon, and affect one or more regions. Assessment of regional and/or whole gut transit times can provide direct measurements and diagnostic information to explain the cause of symptoms, and plan therapy. Purpose Recently, several newer diagnostic tools have become available. The American and European Neurogastroenterology and Motility Societies undertook this review to provide guidelines on the indications and optimal methods for the use of transit measurements in clinical practice. This was based on evidence of validation including performance characteristics, clinical significance, and strengths of various techniques. The tests include measurements of: gastric emptying with scintigraphy, wireless motility capsule, and 13 C breath tests; small bowel transit with breath tests, scintigraphy, and wireless motility capsule; and colonic transit with radioopaque markers, wireless motility capsule, and scintigraphy. Based on the evidence, consensus recommendations are provided for each technique and for the evaluations of regional and whole gut transit. In summary, tests of gastrointestinal transit are available and useful in the evaluation of patients with symptoms suggestive of gastrointestinal dysmotility, since they can provide objective diagnosis and a rational approach to patient management.

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Wireless pH‐motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation

Cited by 181 publications

References 39 publications

Diagnosis and Treatment of Dyssynergic Defecation

Diagnosis and Treatment of Dyssynergic Defecation

Value of 24-hour Delayed Film of Barium Enema for Evaluation of Colon Transit Function in Young Children with Constipation

Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies

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