Wirksamkeitsnachweis von Nimodipin — Ein Beitrag zur Entwicklung geeigneter Prüfmodelle

Kanowski, S.

doi:10.1007/978-3-642-76767-8_6

Cited by 6 publications

(7 citation statements)

References 2 publications

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“…The treatment group demonstrated efficacy of therapy on primary outcome measures, whereas the placebo group was remarkably stable. Other trials with nootropics were designed for a longer period 30–32 . The previous trials with acetylcholine esterase inhibitors also had a relatively long study period of 24–36 weeks 1–6 .…”

Section: Discussionmentioning

confidence: 99%

A Double‐Blind, Placebo‐Controlled, Multicenter Study of Cerebrolysin for Alzheimer's Disease

Bae

Cho

et al. 2000

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

A Double‐Blind, Placebo‐Controlled, Multicenter Study of Cerebrolysin for Alzheimer's Disease

Bae

Cho

et al. 2000

J American Geriatrics Society

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“…This range is comparable to that of the Oder River dikes with historical dike cores (Pohl, 1999). Airfilled porosity values were adopted from the measurements of Kanowski (1977) for the Elbe dikes and summarised in Table 2.…”

Section: Probability Of Seepagementioning

confidence: 99%

Development of dike fragility curves for piping and micro-instability breach mechanisms

Vorogushyn

Merz

Apel

2009

Nat. Hazards Earth Syst. Sci.

117

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Abstract. The paper analyses the prevailing breach mechanisms of fluvial dikes. Piping in the dike foundation and slope failure as a consequence of seepage flow through a dike core (micro-instability) were identified as two of the dominant breach mechanisms for historically-grown dikes along with overtopping and slope macro-instability. For the former two mechanisms the physically-based and empirical process descriptions were reviewed and led to the formulation of the reliability functions. Evaluation of these functions in the Monte Carlo framework for the time dependent load led to the development of fragility functions. These functions indicate the probability of failure of a dike section upon loading and can be computed for each spatially discretised dike section. The probability of breaching is conditioned by the uncertainty in geometrical and geotechnical dike parameters. This uncertainty is explicitly taken into account during computation of the fragility functions in a Monte Carlo simulation. Sensitivity analysis was carried out in order to identify the sensitive geotechnical parameters influencing the distribution of failure probability. The identification of sensitive parameters indicates the priorities in geotechnical measurement campaigns aimed at the assessment of dike stability. The newly developed fragility functions can be applied in flood hazard and risk assessment studies for modelling of dike failures in a probabilistic framework.

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“…Results from animal studies indicate that nimodipine also has effects on the central nervous system which may be characterized as cerebroprotective [7]. Several clinical studies in elderly patients suffering from primary degenerative dementia or multi-infarct dementia suggest that nimodipine has a beneficial effect on impaired brain functions in old age [8][9][10][11]. The purpose of this study was to investigate possible interactions between nimodipine and diazepam, a drug which is often prescribed for elderly patients [12,13].…”

Section: Introductionmentioning

confidence: 99%

Lack of interaction between diazepam and nimodipine during chronic oral administration to healthy elderly subjects.

Heine¹,

Weyer²,

Breuel³

et al. 1994

Brit J Clinical Pharma

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Wirksamkeitsnachweis von Nimodipin — Ein Beitrag zur Entwicklung geeigneter Prüfmodelle

Cited by 6 publications

References 2 publications

A Double‐Blind, Placebo‐Controlled, Multicenter Study of Cerebrolysin for Alzheimer's Disease

A Double‐Blind, Placebo‐Controlled, Multicenter Study of Cerebrolysin for Alzheimer's Disease

Development of dike fragility curves for piping and micro-instability breach mechanisms

Lack of interaction between diazepam and nimodipine during chronic oral administration to healthy elderly subjects.

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