WITHDRAWN: Early Post-partum Glucose Intolerance, Metabolic Syndrome and Gestational Diabetes Mellitus Determinants After Assisted Conception: A Prospective Cohort Study

Abstract

Background: This study aimed to determine the prevalence of postpartum metabolic syndrome (MetS), glucose intolerance and other determinants, 6-12 weeks postpartum in women with assisted reproduction technology conception gestational diabetes mellitus diagnosis (ART-GDM) compared to women with spontaneous conception and GDM diagnosis (SC-GDM).Methods: In this prospective cohort study, two groups consisted of 62 ART-GDM and 64 SC-GDM singleton pregnant women were followed 6-12 weeks after delivery for postpartum MetS. Fasting glucose, 75-g 2-h OGTT and lipid profile were assessed. Waist and hip circumference, and systolic and diastolic blood pressures (BP) were measured at post- partum. Clinical, para clinical and obstetric data were recorded from registry offices. The prevalence of MetS and glucose intolerance were determined. Predictors of Mets and glucose intolerance were determined by logistic regression. Results: The prevalence of postpartum MetS was 20.8% in ART-GDM women and 10.9% in SC-GDM, P=0.123). Mean postpartum BMI and systolic BP were significantly higher in the ART-GDM group (P=0.016 and P=0.027, respectively). Adverse pregnancy outcomes were significantly higher in the ART-GDM group. Postpartum glucose intolerance prevalence did not vary significantly between the groups. Family history of diabetes was a predictive factor for postpartum MetS and glucose intolerance 6-12 weeks after delivery.Conclusions: Early postpartum MetS and glucose intolerance prevalence after assisted conception did not vary significantly; however, postpartum BMI and systolic BP were significantly higher in the ART-GDM group. Lifestyle modification program and long-term health care of ART women with GDM diagnosis can be recommended. Further studies with larger sample size and longer follow-up are necessary to verify our findings.