Within‐day bidirectional associations between physical activity and affect: A real‐time ambulatory study in persons with and without depressive and anxiety disorders

Difrancesco, Sonia; Penninx, Brenda W. J. H.; Merikangas, Kathleen R.; Hemert, Albert M. van; Riese, Harriëtte; Lamers, Femke

doi:10.1002/da.23298

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Key challenges in building robust and generalizable relapse prediction models in MDD include class imbalance caused by relatively low prevalence of the relapse events and considerable intra and inter-individual variability in the active and passive features associated with depression severity 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

Personalized relapse prediction in patients with major depressive disorder using digital biomarkers

Vairavan,

Rashidisabet,

et al. 2023

Sci Rep

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Major depressive disorder (MDD) is a chronic illness wherein relapses contribute to significant patient morbidity and mortality. Near-term prediction of relapses in MDD patients has the potential to improve outcomes by helping implement a ‘predict and preempt’ paradigm in clinical care. In this study, we developed a novel personalized (N-of-1) encoder-decoder anomaly detection-based framework of combining anomalies in multivariate actigraphy features (passive) as triggers to utilize an active concurrent self-reported symptomatology questionnaire (core symptoms of depression and anxiety) to predict near-term relapse in MDD. The framework was evaluated on two independent longitudinal observational trials, characterized by regular bimonthly (every other month) in-person clinical assessments, weekly self-reported symptom assessments, and continuous activity monitoring data with two different wearable sensors for ≥ 1 year or until the first relapse episode. This combined passive-active relapse prediction framework achieved a balanced accuracy of ≥ 71%, false alarm rate of ≤ 2.3 alarm/patient/year with a median relapse detection time of 2–3 weeks in advance of clinical onset in both studies. The study results suggest that the proposed personalized N-of-1 prediction framework is generalizable and can help predict a majority of MDD relapses in an actionable time frame with relatively low patient and provider burden.

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Section: Introductionmentioning

confidence: 99%

Personalized relapse prediction in patients with major depressive disorder using digital biomarkers

Vairavan,

Rashidisabet,

et al. 2023

Sci Rep

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Within‐day bidirectional associations between physical activity and affect: A real‐time ambulatory study in persons with and without depressive and anxiety disorders

Difrancesco

Penninx

Merikangas

et al. 2022

Depression and Anxiety

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Background: Ambulatory assessments offer opportunities to study physical activity level (PAL) and affect at the group and person-level. We examined bidirectional associations between PAL and affect in a 3-h timeframe and evaluated whether associations differ between people with and without current or remitted depression/anxiety. Methods: Two-week ecological momentary assessment (EMA) and actigraphy data of 359 participants with current (n = 93), remitted (n = 176), or no (n = 90) Composite International Diagnostic Interview depression/anxiety diagnoses were obtained from the Netherlands Study of Depression and Anxiety. Positive affect (PA) and negative affect (NA) were assessed by EMA 5 times per day. Average PAL between EMA assessments were calculated from actigraphy data.Results: At the group-level, higher PAL was associated with subsequent higher PA (b = 0.109, p < .001) and lower NA (b = −0.043, p < .001), while higher PA (b = 0.066, p < .001) and lower NA (b = −0.053, p < .001) were associated with subsequent higher PAL. The association between higher PAL and subsequent lower NA was stronger for current depression/anxiety patients than controls (p = .01). At the person-level, analyses revealed heterogeneity in bidirectional associations.Conclusions: Higher PAL may improve affect, especially among depression/anxiety patients. As the relationships vary at the person-level, ambulatory assessments may help identify who would benefit from behavioral interventions.

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The Within-Subject Association of Physical Behavior and Affective Well-Being in Everyday Life: A Systematic Literature Review

Timm,

Giurgiu,

Ebner-Priemer

et al. 2024

Sports Med

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Background The interplay of physical activity (PA) with affective well-being (AWB) is highly critical to both health behaviors and health outcomes. Current prominent theories presume AWB to be crucial for PA maintenance, and PA is evidenced to foster mental health. However, thus far, PA-AWB associations have mainly been researched in laboratory settings and with interventional designs, but the everyday life perspective had not been focused on, mostly due to technological limitations. In the course of digitization, the number of studies using device-based methods to research the within-subject association of physical activity and affective well-being (PA-AWB) under ecological valid conditions increased rapidly, but a recent comprehensive systematic review of evidence across populations, age groups, and distinct AWB components remained inconclusive. Objectives Therefore, we aimed to firstly review daily-life studies that assessed intensive longitudinal device-based (e.g., electronic smartphone diaries and accelerometry) and real-time PA-AWB data, secondly to develop and apply a quality assessment tool applicable to those studies, and thirdly to discuss findings and draw implications for research and practice. Methods To this end, the literature was searched in three databases (Web of Science, PubMed, Scopus) up to November 2022. The systematic review followed the PRISMA guidelines and had been pre-registered (PROSPERO id: CRD42021277327). A modified quality assessment tool was developed to illustrate the risk of bias of included studies. Results The review of findings showed that, in general, already short PA bouts in everyday life, which clearly differ from structured exercise sessions, are positively associated with AWB. In particular, feelings of energy relate to incidental (non-exercise and unstructured) activity, and PA-AWB associations depend on population characteristics. The quality assessment revealed overall moderate study quality; however, the methods applied were largely heterogeneous between investigations. Overall, the reviewed evidence on PA-AWB associations in everyday life is ambiguous; for example, no clear patterns of directions and strengths of PA-AWB relationships depending on PA and AWB components (such as intensity, emotions, affect, mood) emerged. Conclusions The reviewed evidence can fuel discussions on whether the World Health Organization’s notion “every move counts” may be extended to everyday life AWB. Concurrently, the PA-AWB relationship findings endorse prominent theories highlighting the critical role of AWB in everyday PA engagement and maintenance. However, the review also clearly highlights the need to advance and harmonize methodological approaches for more fine-grained investigations on which specific PA/AWB characteristics, contextual factors, and biological determinants underly PA-AWB associations in everyday life. This will enable the field to tackle pressing challenges such as the issue of causality of PA-AWB associations, which will help to shape and refine existing theories to ultimately predict and improve health behavior, thereby feeding into precision medicine approaches.

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Within‐day bidirectional associations between physical activity and affect: A real‐time ambulatory study in persons with and without depressive and anxiety disorders

Cited by 5 publications

References 35 publications

Personalized relapse prediction in patients with major depressive disorder using digital biomarkers

Personalized relapse prediction in patients with major depressive disorder using digital biomarkers

Within‐day bidirectional associations between physical activity and affect: A real‐time ambulatory study in persons with and without depressive and anxiety disorders

The Within-Subject Association of Physical Behavior and Affective Well-Being in Everyday Life: A Systematic Literature Review

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