Within-network brain connectivity in Crohn’s disease patients with gadolinium deposition in the cerebellum

Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective

“…Though Mallio et al. (2019, 2020) had revealed that the dentate nucleus where gadolinium predominantly accumulates did not show significant functional connectivity changes, it shed light on us that we should be more careful on the research design and consider those clinical factors that relate closely to CD patients.…”

“…In most cases, patients with CD undergo administration of contrast agent for abdominopelvic MRI to differentiate active from quiescent disease, which makes them more prone to gadolinium accumulation in brain. Though Mallio et al (2019Mallio et al ( , 2020 had revealed that the dentate nucleus where gadolinium predominantly accumulates did not show significant functional connectivity changes, it shed light on us that we should be more careful on the research design and consider those clinical factors that relate closely to CD patients.…”

Exploring joint patterns of brain structure and function in inflammatory bowel diseases using multimodal data fusion

“…Functional MRI (fMRI) studies in CD have applied experimental study designs that examined the processing of stressful tasks 1,3 or visceral 11 stimuli, or analyzed resting-state data to examine intrinsic brain function. 7,[16][17][18] Considering functional imaging findings in CD, stress-related increased activity in midcingulate cortex 1 and medial temporal lobe regions 3 have been observed. Uncertainty regarding upcoming rectal discomfort was found to be associated with higher activation of cingulate and insular cortex, amygdala, and thalamus in CD patients compared to controls.…”

“…11 Studies investigating intrinsic neural function in patients with IBD using resting-state functional MRI (rs-fMRI) revealed activity changes in several brain areas, particularly in anterior cortical midline regions. [15][16][17] A recent meta-analysis on structural and functional brain changes in CD highlighted lower intrinsic neural activity in cingulate cortex and paracentral lobule, as well as lower gray matter volume (GMV) in the medial frontal gyrus. 19 In contrast to CD, neuroimaging data in UC are very scarce.…”

Gadolinium-based contrast agents: What we learned from acute adverse events, nephrogenic systemic fibrosis and brain retention

“…Auch in weiteren Studien konnte bislang keine eindeutige Korrelation von Gadolinium-Retention und klinischen bzw. neurologischen Korrelaten gefunden werden [53][54][55][56].…”