Within-person variation in the postprandial lipemic response of healthy adults

Abstract

This work showed that the within-person variability in postprandial lipemic response is low in most healthy adults. It also showed that variability in this response is associated with a defined set of phenotypic and genotypic characteristics.

Postprandial lipemia as a cardiometabolic risk factor

“…SNPs in the following genes: glucokinase regulatory protein (GCKR), IL-6, perilipin (PLIN), transcription factor 7-like 2 (TCF7L2), the IL-1 pathway (IL1alpha and IL1beta), and TLR4 were also reported to impact postprandial lipemia 69,70 although the mechanisms for these associations are unclear.…”

“…As expected most of the SNPs are present in genes coding for apolipoproteins, lipid metabolism enzymes, transporter proteins, and receptors, as well as in emerging genes such as peroxisome proliferator-activated receptors (PPARs), angiopoietin-like protein 4 (ANGPLT4) and perilipin. Additional associations were reported with inflammatory genes such as interleukin-6 (IL-6) or toll like receptors (TLRs) 70 .…”

“…Also a SNP in APOA1, the main protein of HDL 14 , may impact postprandial lipemia. Homozygotes for the minor allele of APOA1-2803G/A display a lower increase in both total TGs and large TRL TGs after a saturated fat overload 70,71 ; whether this relates to the apoA-I fraction present on the surface of nascent chylomicrons remains to be addressed. ApoA-IV regulates dietary fat absorption and chylomicron synthesis, activates lecithin cholesterol acyltransferase (LCAT), and modulates LPL activation by apoC-II.…”

Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach

“…Detailed information on the study has been previously published. 23,24 For the present study, participants (n=188) who had complete dietary data and lipidomic data were included (Table 1).…”

“…Following a 12 hour overnight fast, serum and plasma samples were collected into serum tubes containing a clot activator coating, EDTA-coated and lithium heparin containing tubes for plasma isolation as previously described 23,24 . Serum samples were allowed time to clot (30 minutes) at room temperature.…”