Wnt 3a-Modified Scaffolds Improve Nerve Regeneration by Boosting Schwann Cell Function
Ruichao He,
Yu Wei,
Shi Yan
et al.
Abstract:A pivotal approach in engineering artificial peripheral nerve sheaths encompasses the augmentation of the regenerative microenvironment via the manipulation of Schwann cells (SCs). Our investigation employed single-cell sequencing analysis to elucidate the potential functions of Schwann cells and the Wnt pathway in facilitating peripheral nerve regeneration. In vitro studies showed that activating the Wnt signaling pathway promotes the transition to repair SCs, boosting their growth, movement, and immune funct… Show more
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