Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running

Fujimaki, Shin; Hidaka, Ryo; Asashima, Makoto; Takemasa, Tohru; Kuwabara, Tomoko

doi:10.1074/jbc.m113.539247

Cited by 69 publications

(65 citation statements)

References 52 publications

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“…Quiescent satellite cells are Pax7‐positive but are negative for myogenic Myf5 and MyoD. In contrast, activated satellite cells co‐express Myf5 and MyoD together with Pax7 . In our first experiment, Pax7 expression was relatively high (95.3%) in uMDSCs according to the flow cytometry, while the expression of Myf5 was 56.65%, which meant that most satellite cells were activated cells.…”

Section: Discussionmentioning

confidence: 61%

“…In contrast, activated satellite cells co-express Myf5 and MyoD together with Pax7. 20 In our first experiment, Pax7 expression was relatively high (95.3%) in uMDSCs according to the flow cytometry, while the expression of Myf5 was 56.65%, which meant that most satellite cells were activated cells. In our subsequent study, the uMDSCs treated with 2% horse serum induction medium formed many myotubes (Figure 1).…”

Section: Discussionmentioning

confidence: 71%

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Low‐intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway

Wang

Zhou

Banie

et al. 2017

Neurourology and Urodynamics

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In conclusion, this experiment reveals that rat uMDSCs can be isolated successfully and can form myotubes in vitro. PERK/ATF4 pathway was involved in myotube formation, and L6 rat myoblast cells were activated by Li-ESWT to form myotubes. These findings suggest that PERK/ATF4 pathway is activated by Li-ESWT. This study elucidates one of the biochemical pathways responsible for the clinical improvements seen after Li-ESWT. It is possible that this information will help to establish Li-ESWT as an acceptable treatment modality and may help to further refine the use of Li-ESWT in the clinical practice of medicine.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 71%

Low‐intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway

Wang

Zhou

Banie

et al. 2017

Neurourology and Urodynamics

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“…Furthermore, Pkp2 haploinsufficiency led to sodium current deficits in murine hearts, and PKP2 knockdown in HL-1 myocytes produced features of ARVD/C (11,12). However, the initial report of (20,21). Peroxisome proliferator-activated receptor (PPAR)-g and PPAR-a stimulation of induced pluripotent stem cell-derived cardiomyocytes from patients with ARVD/C leads to exaggerated lipogenesis and apoptosis, which implicates this pathway in ARVD/ C pathogenesis (22).…”

mentioning

confidence: 90%

Further Evidence of Harm From Exercise in ARVD/C

Judge

Chelko

2015

Journal of the American College of Cardiology

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“…Voluntary wheel running in mice converts satellite cells to the activated state due to accelerated Wnt signaling (Fujimaki et al, 2014). In addition to activating satellite cells, Wnt/β-catenin signaling has been found to induce hTERT mRNA expression and telomerase activity in various tumor cell lines (Zhang et al, 2012).…”

Section: Potential Pathways For Exercise Dependent Telomerase Activitmentioning

confidence: 99%

The influence of physical exercise and sports on telomere length - A model for telomere length and telomerase activity regulation based on a comparative assessment of literature

Fröhlich

2016

Preprint

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Based upon a comprehensive analysis of current literature and by combining a molecular biology and a sports science perspective, this review examines (1) if a correlation between physical activity load and telomere length (TL) exists, and (2) comprehensively analyses and integrates molecular pathways regulating exercise dependent TL dynamics. The focus is on TL in leukocytes and muscle tissue in middle to advanced aged subjects. Regarding item (1), a strong tendency for an increase in mean leukocyte TL was found for exercise energy expenditures up to about 2∙103 kcal/week, while for higher activity levels no conclusive statement can be made. Conversely, research on skeletal muscle TL so far is quite limited but suggests that physical exercise with prolonged eccentric muscle contractions rather acts to shorten telomeres, while sports with little eccentric contractions might rather act to lengthen telomeres. As to item (2), a model for hypothetical pathways for exercise dependent telomerase activity regulation is proposed by consolidating findings of different studies in different cells. Consistent with this pathway model, various studies report increased telomerase transcription or activation by exercise. Moreover, a qualitative overall model for endurance exercise related TL dynamics is presented. It considers telomeres as dynamic structures in equilibrium between telomere shortening (e.g., cellular turnover, oxidative stress, inflammation) and telomere lengthening (e.g., telomerase activity, telomerase recruitment) effects. A negative feedback-loop mediated by enhanced telomerase recruitment to short telomeres is assumed to counteract too excessive TL alterations. Finally, a proposal is put forth for future research on exercise dependent telomere dynamics by adopting a systems biology approach to develop mathematical models that properly integrate the complexity of the interacting variables.

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Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running

Cited by 69 publications

References 52 publications

Low‐intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway

Low‐intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway

Further Evidence of Harm From Exercise in ARVD/C

The influence of physical exercise and sports on telomere length - A model for telomere length and telomerase activity regulation based on a comparative assessment of literature

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