2024
DOI: 10.1387/ijdb.240007vp
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Wnt target gene Ascl4 is dispensable for skin appendage development

Verdiana Papagno,
Ana-Marija Sulic,
Jyoti P. Satta
et al.

Abstract: The development of skin appendages, including hair follicles, teeth and mammary glands is initiated through the formation of the placode, a local thickening of the epithelium. The Wnt/β-catenin signaling cascade is an evolutionary conserved pathway with an essential role in placode morphogenesis, but its downstream targets and their exact functions remain ill defined. In this study, we identify Achaete-scute complex-like 4 (Ascl4) as a novel target of the Wnt/β-catenin pathway and demonstrate its expression pa… Show more

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