Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

Sun, Yang; Zhao, Yue; Yao, Jing; Zhao, Li; Wu, Zhao-Qiu; Wang, Yu; Pan, Di; Hua, Miao; Guo, Qinglong; Lu, Na

doi:10.1016/j.bcp.2015.02.002

Cited by 144 publications

(90 citation statements)

References 66 publications

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“…The transcription factor NF-jB is an important upstream modulator of inflammatory mediators such as TNF-a, IL-1ß, PGE 2 and NO [19,20]. NF-jB has been identified as the main target for the treatment of inflammatory diseases [21,22].…”

Section: Discussionmentioning

confidence: 99%

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Zhou

et al. 2015

Neurochem Res

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Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Zhou

et al. 2015

Neurochem Res

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“…It has been reported that the polymorphism in the Nlrp3 gene is closely associated with the colitis severity and progression in patients with IBD (111, 112). In addition, studies in macrophages and mice models of IBD have uncovered the link between the abnormal activation of the NLRP3 inflammasome and colitis (113, 114). It was recently reported that oral administration of titanium dioxide (TiO 2 ) nanoparticles aggravated the severity of IBD through a mechanism involving the activation of the NLRP3 inflammasome in DSS-induced colitis mice or UC patents (108).…”

Section: The Roles Of Autophagy In Ibdmentioning

confidence: 99%

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

Peng

Shao

et al. 2017

Front. Immunol.

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Intestinal mucosal barrier, mainly composed of the intestinal mucus layer and the epithelium, plays a critical role in nutrient absorption as well as protection from pathogenic microorganisms. It is widely acknowledged that the damage of intestinal mucosal barrier or the disturbance of microorganism balance in the intestinal tract contributes greatly to the pathogenesis and progression of inflammatory bowel disease (IBD), which mainly includes Crohn’s disease and ulcerative colitis. Autophagy is an evolutionarily conserved catabolic process that involves degradation of protein aggregates and damaged organelles for recycling. The roles of autophagy in the pathogenesis and progression of IBD have been increasingly studied. This present review mainly describes the roles of autophagy of Paneth cells, macrophages, and goblet cells in IBD, and finally, several potential therapeutic strategies for IBD taking advantage of autophagy.

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“…It is well known that the production of inflammatory cytokines TNF-α and IL-1β is regulated by NF-κB [19]. Normally, NF-κB is maintained in the cytoplasm where it is bound to IκB inhibitor proteins.…”

Section: Discussionmentioning

confidence: 99%

Sappanone A protects mice against cisplatin-induced kidney injury

Kang

Zhao

Chen

et al. 2016

International Immunopharmacology

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Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

Cited by 144 publications

References 66 publications

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

Sappanone A protects mice against cisplatin-induced kidney injury

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