Research and Training in Tropical Diseases (TDR) with the support of PAHO joined, to issue a call for research proposals. The aim was to combine support for research capacity strengthening in the context of an emerging epidemic, with investigations into the multifaceted but largely unknown nature of the Zika virus outbreak. Researchers based in the countries most affected by the epidemic were encouraged to apply for funding that prioritized implementation research projects to support an evidence-based, comprehensive public health response. 3In many of the Zika-affected countries in Latin America, socioeconomic inequities and legislation limit access to sexual and reproductive health services such as modern contraceptives and safe abortion. 4 The Zika epidemic exposed this vulnerability further, given its dire consequences for pregnant women. Viral characteristics, such as sexual transmission of the virus caused by it persisting in semen several months after infection 5 and the highly contextualized varying incidence rates of microcephaly following Zika infection during pregnancy, highlighted how inequities in and unmet access to sexual and reproductive health services determine the epidemic's impact.The combined effort between the WHO-hosted special research programs and the WHO regional office-focusing on infectious diseases of poverty and sexual and reproductive health and rights-enabled WHO to address the need for cross-cutting efforts between research areas and disciplines, in response to a complex emergency like the Zika epidemic. Ranging from studies on the spatial distribution of the virus and its relative risk, to articles on understanding how the virus impacts women's reproductive choices in communities without access to safe abortion, the papers in this Supplement illustrate the broad variety of perspectives necessary to ensure an understanding of the Zika virus context and to tailor the necessary response.The articles included in this Supplement come from Brazil, Colombia, and Peru. Colleagues implementing a study in Colombia (Forero et al. 6 ) This is an open access article distributed under the terms of the Creative Commons Attribution IGO License which permits unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or the article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's URL.