Work disability in early rheumatoid arthritis.

Doeglas, D; Suurmeijer, T; Krol, Boudien; Sanderman, Robbert; Leeuwen, M. van; Rijswijk, Martin van

doi:10.1136/ard.54.6.455

Cited by 108 publications

(113 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Loss of physical function leaves patients unable to work or manage their daily activities. Work disability can occur early in the course of disease (4,(26)(27)(28). Moreover, to cope with increasing work disability, patients often attempt to reduce the number of working hours or change their type of work before being forced by disease-related debilitation to leave the workforce.…”

Section: Discussionmentioning

confidence: 99%

Infliximab treatment maintains employability in patients with early rheumatoid arthritis

Smolen

Han²,

Heijde

et al. 2006

Arthritis & Rheumatism

108

View full text Add to dashboard Cite

Objective. To evaluate the impact of infliximab therapy on the employment status of patients with early rheumatoid arthritis (RA).Methods. Methotrexate (MTX)-naive patients with active early RA were randomly allocated to receive MTX plus placebo or MTX plus infliximab (3 mg/kg or 6 mg/kg) at weeks 0, 2, and 6 and then every 8 weeks through week 46. Data for patients younger than age 65 years were included in the analyses. A patient was categorized as employable if he or she was employed or felt well enough to work if a job were available.Results. The change in actual employment was not significantly different between patients receiving MTX plus infliximab and those receiving MTX plus placebo (0.5% versus 1.3%; P > 0.5). However, the proportion of patients whose status changed from employable at baseline to unemployable at week 54 was smaller in the group receiving MTX plus infliximab compared with that in the group receiving MTX alone (8% versus 14%; P ‫؍‬ 0.05). Patients who were treated with infliximab plus MTX had a significantly greater likelihood of improvement rather than deterioration in employability (odds ratio 2.4; P < 0.001); this likelihood was not significantly greater in patients receiving MTX alone. The proportion of employed patients who lost workdays during the trial was smaller in the MTX plus infliximab group than in the MTX-alone group (P ‫؍‬ 0.010). Conclusion. The actual employment rates among patients in the 2 treatment groups were not different. However, patients with early RA who were treated with MTX plus infliximab had a higher probability of maintaining their employability compared with those who were treated with MTX alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Infliximab treatment maintains employability in patients with early rheumatoid arthritis

Smolen

Han²,

Heijde

et al. 2006

Arthritis & Rheumatism

108

View full text Add to dashboard Cite

show abstract

“…Social support and psychological distress in rheumatoid arthritis: a 4-year prospective study Jozef Benka 1,2 , Iveta Nagyova 1,3 , Jaroslav Rosenberger 1,3,4 , Anna Calfova Psychological distress is a relevant problem in rheu-• matoid arthritis patients and should be recognized early in the disease as it might reflect a lack of social resources which can be crucial in the further course of the disease. Special attention should be paid to different types • of social support in relation to psychological distress, which might improve targeting psychosocial interventions.…”

Section: Research Papermentioning

confidence: 99%

“…performing social roles, all of which has a great impact on a patient's psychological functioning [4,5]. Due to the nature of the disease and especially its erratic pattern [6], longitudinal studies have been carried out and are still required to investigate and clarify the impact of RA [7,8].…”

Section: Research Papermentioning

confidence: 99%

Social support and psychological distress in rheumatoid arthritis: a 4-year prospective study

Benka

Nagyová

Rosenberger

et al. 2011

Disability and Rehabilitation

View full text Add to dashboard Cite

Introduction:The objective of the study was to investigate the course of psychological distress in early rheumatoid arthritis patients and to explore the strength of its associations with disease-related variables over time. A further aim focused specifically on the associations between social support and psychological distress. Methods: The study had a longitudinal design, with four annual measurements over consecutive years. The course and stability of psychological distress on the individual level were investigated via test-retest correlation coefficients and changes over time were studied using the Friedman test for repeated measurements. Hierarchical regression analysis was performed to analyze the multilinear associations of disease activity, functional disability, joint tenderness, pain and social support with psychological distress. Results: Significant cross-sectional associations were found among functional disability, joint tenderness, pain, emotional support, instrumental support and psychological distress. However, after controlling for the erratic pattern of the disease and the relevant variables, only initial psychological distress and emotional support retained a significant relationship with psychological distress. The final regression model, in which functional disability, pain, emotional support and initial psychological distress were significant variables, explained 36% of the variance in psychological distress. Conclusion:The study stresses the importance of initial psychological distress, which was found to have the highest correlation with psychological distress experienced 4 years later. In addition, higher emotional support and lower pain were found to be the only variables independently associated with lower levels of psychological distress after controlling for the relevant variables.

show abstract

“…An important observation over the last two decades is that work status is not explained by disease severity alone, but by patient characteristics, work duties, and psychological status (3)(4)(5)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Although work disability occurs with roughly equal frequency in men and women in many study populations (3,7,8,12,19,21), the relative importance of factors that explain the onset of work disability is likely to differ between men and women because of the social context that defines role expectations and work performance.…”

Section: Introductionmentioning

confidence: 99%

Differences by sex in correlates of work status in rheumatoid arthritis patients

Roos

Callahan

1999

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To examine differences by sex in correlates of work status in rheumatoid arthritis (RA) patients seen in rheumatology clinical settings.Methods. Associations of demographic factors, occupation, duration of RA, and scores for disease and psychological scales with work status according to sex were examined in a cross-sectional study of 960 RA patients, aged 18 -64 years, of whom 451 were working and 254 were work-disabled. Comparisons of characteristics were conducted by logistic regression between working and work-disabled, and between working and not working subjects.Results. For both men and women, the odds of work disability increased with age, duration of RA, nonwhite race, and scores indicating high levels of functional disability, pain, and helplessness. Workdisabled women were more likely than working women to have less than a high school education or a nonprofessional occupation, compared with little association of these variables with work disability in men. Unmarried men were more likely to be workdisabled than working, while marital status was not associated with work disability in women. Differences by sex in the associations of pain and helplessness scores with work disability were also observed. Similar results were observed in associations of these characteristics when the outcome was coded as working versus not working. Conclusions.These findings indicate some differences between men and women with RA in correlates of work disability that may help to more effectively target interventions. A patient's sex should be an important consideration in studies of work disability due to arthritis.

show abstract

Work disability in early rheumatoid arthritis.

Cited by 108 publications

References 22 publications

Infliximab treatment maintains employability in patients with early rheumatoid arthritis

Infliximab treatment maintains employability in patients with early rheumatoid arthritis

Social support and psychological distress in rheumatoid arthritis: a 4-year prospective study

Differences by sex in correlates of work status in rheumatoid arthritis patients

Contact Info

Product

Resources

About