Working Memory Alterations Plays an Essential Role in Developing Global Neuropsychological Impairment in Duchenne Muscular Dystrophy

Abstract

BackgroundNeuropsychological profile of Indian Duchenne muscular dystrophy (DMD) subjects remains unidentified and needs to be evaluated.MethodsA total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsychological assessment. The factor indexes were derived from various components of Malin’s Intelligence Scale for Indian Children (MISIC) and Rey Auditory Verbal Learning Test (RAVLT).ResultsPoor verbal and visual memory profiles were demonstrated by DMDs, which include RAVLT-immediate recall (IR) (p = 0.042), RAVLT-delayed recall (DR) (p = 0.009), Rey–Osterrieth complex figure test (RCFT)-IR (p = 0.001), and RCFT-DR (p = 0.001). RAVLT-memory efficiency index demonstrated poor verbal memory efficiency (p = 0.008). Significant differences in the functioning of working memory axis [RAVLT T1 (p = 0.015), recency T1 (p = 0.004), Digit Span Backward (p = 0.103)] were observed along with reduced performance in visuomotor coordination, visuospatial, and visual recognition abilities. Block designing efficiency index and attention fraction showed a normal performance in DMD kids.ConclusionWorking memory deficits were found to be the crucial element of cognitive functioning in DMD cases. Working memory interventions may be beneficial to improve the neuropsychological profile in DMD.

Adults living with Duchenne muscular dystrophy: old and new challenges in a cohort of 19 patients in their third to fifth decade

“…Cognitive network dysfunction is well described in DMD patients from infancy, ranging from intellectual disabilities to impaired verbal and memory skills, attention‐deficit hyperactivity disorder, autism spectrum disorder and obsessive‐compulsive disorder [8, 9, 24–32]. It can be inferred from our study cohort that the cognitive and psychiatric profile may continue to have an impact on the overall health and care requirements of DMD patients in their adulthood.…”

Dietary Intake of Polyphenols Enhances Executive/Attentional Functioning and Memory with an Improvement of the Milk Lipid Profile of Postpartum Women from Argentina

“…After 30 min, the participant must again remember the words of the first list (Trial A7-long term delayed free recall-), and finally identify them on a printed sheet with 75 words (visual recognition). For this study, a set of traditional and novel scores were obtained from RAVLT ( Alviarez-Schulze et al 2022 ; Miranda et al 2021a ; Tyagi et al 2021 ).…”

Visuospatial representation in patients with mild cognitive impairment: Implication for rehabilitation

“…The lack of studies on the neural underpinnings of visual attention in patients with MCI has resulted in the following gaps: Future studies in this area should be conducted to fill these gaps by examining the neural underpinnings of allocentric and egocentric representations of space in patients with MCI. The use of basic scales to decipher visual attention in MCI and/or other similar conditions in resource-limited settings [86] and the use of mobile devices in diagnosis [87] would be useful. Studies in this area would be useful in contributing to the optimization of neurological rehabilitation for MCI.…”