Wound Cleansing and Irrigation

Trott, Alexander T.

doi:10.1016/b978-0-323-07418-6.00007-1

Cited by 8 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Povidone-iodine (complex form) has been claimed for infectious disease management, disease control, treatment of giant fornix syndrome, control of ocular infections, ear wash, and irrigating fluid for wound surgery. The complex form of PVP with iodine results in a gradual release of the potent antibacterial agent, iodine thereby reducing the toxicity of iodine [ 170 ].…”

Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

294

172

View full text Add to dashboard Cite

Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

show abstract

Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

294

172

View full text Add to dashboard Cite

show abstract

“…According to previous results, it was possible to observe that povidone iodine has less effect on reducing bacteria and organic material on S-HCW hands. Even though it has been demonstrated that povidone iodine diluted to a 1% concentration or lower can be applied safely to wounds [32], this dilution is more likely to be ineffective in local bacterial control [33], resulting in povidone iodine having a shorter protective effect against bacterial buildup on the skin after HW [32]. In this sense, chlorhexidine is a better option than povidone iodine for skin preparation when a substantive effect is desired for procedures such as skin preparation for surgery or HW before surgery [34].…”

Section: Discussionmentioning

confidence: 99%

Monitoring the effectiveness of surgical handwashing in healthcare workers of a fourth level operating room using bioluminescence assays

González

Espinosa²,

Ardila³

et al. 2022

ing. Solidar

View full text Add to dashboard Cite

Aims: To assesses the effectiveness of surgical handwashing (S-HW) in healthcare workers (HCWs) in terms of organic material and bacteria elimination by means of bioluminescence assays. Methods: 62-HCWs were subjected to bioluminescence analyses to determine adenosine triphosphate (ATP) and colony forming units (CFU) of Enterobacteriaceae (EB) and E. coli before and after S-HW. A checklist to evaluate adherence to hand hygiene (HH) protocol was implemented. Results: ATP before HH (510.9/RLU) was reduced after S-HW (54.6/RLU), evidencing a significant decrease (p=0.001). Regarding the bacteria, 26.6/CFU and 4/CFU for EB and E. coli were reported before S-HW, respectively. After S-HW, CFU decreased for EB (21.8/CFU) and E. coli (3.5/CFU) without showing a significant reduction (p=0.679). Low ATP did not evidence a direct relation with EB (p=0.082) and E. coli (p=0.680) reduction. Surgical instrument professionals (p=0.001), general surgeons (p=0.001), residents (p=0.017), orthopedists (p=0.029) and otolaryngologists (p=0.029) evidenced a reduction in ATP after S-HW. Factors such as S-HW direction, surgical soap, moments and time of S-HW implemented showed a statistically significant difference in reduction of ATP, but not in CFU. Conclusion: Although there was a reduction in elimination of ATP, there was no evidence of a decrease in bacteria. This finding not only allowed to identify potential errors in S-HW processes, but also permitted to generate strategies to improve HH to prevent healthcare-associated infections.

show abstract

“…The primary focus in management of bite wounds is thorough wound cleansing by high-pressure, pulsed irrigation with copious amount of normal saline [33]. Pulsatile jet lavage at pressure of 50-70 psi has been shown to be highly effective in decreasing the bacterial load and removing the particulate matters [34]; however, it may cause soft tissue disruption [35]. Thus, use of pulsating jet device has been reserved for grossly soiled wounds [35].…”

Section: Surgical Management Of Bite Woundsmentioning

confidence: 99%

“…Pulsatile jet lavage at pressure of 50-70 psi has been shown to be highly effective in decreasing the bacterial load and removing the particulate matters [34]; however, it may cause soft tissue disruption [35]. Thus, use of pulsating jet device has been reserved for grossly soiled wounds [35]. Alternatively, time honored method of manual irrigation using 20-35 ml syringe with 18-20 gauge needle is widely recommended [21].…”

Section: Surgical Management Of Bite Woundsmentioning

confidence: 99%

“…Alternatively, time honored method of manual irrigation using 20-35 ml syringe with 18-20 gauge needle is widely recommended [21]. The volume of irrigant varies from 150 to 250 ml [32]; however, larger amount may be needed depending on level of contamination and size of wound [35]. For punctured wound, high pressure irrigation device with flexible catheter is used [17].…”

Section: Surgical Management Of Bite Woundsmentioning

confidence: 99%

See 1 more Smart Citation

Animal Inflicted Maxillofacial Injuries: Treatment Modalities and Our Experience

Yadav

Jaisani

Pradhan

et al. 2016

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

show abstract

Wound Cleansing and Irrigation

Cited by 8 publications

References 34 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Monitoring the effectiveness of surgical handwashing in healthcare workers of a fourth level operating room using bioluminescence assays

Animal Inflicted Maxillofacial Injuries: Treatment Modalities and Our Experience

Contact Info

Product

Resources

About