Wound dressing with sustained anti-microbial capability

Loke, Weng‐Keong; Lau, Sok-Kiang; Lim, Lee Yong; Khor, Eugene; Sum, Chow Kok

doi:10.1002/(sici)1097-4636(2000)53:1<8::aid-jbm2>3.3.co;2-v

Cited by 42 publications

(58 citation statements)

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“…Traditional antimicrobial elastomers and gels require incorporation of antibiotics or inorganic materials like silver nanoparticles (Thomas et al, 2007; Singh et al, 2013). Thus, high swelling ratio could lead to a burst release of these bacteria-killing agents that limits the in vivo anti-infection outcomes, especially for long-term (Loke et al, 2000). CA-based elastomers and hydrogels provide unique intrinsic antimicrobial properties, thus the swelling can be tailored to meet other requirements, e.g., mechanical demands, in tissue engineering without concerns of the burst release.…”

Section: Discussionmentioning

confidence: 99%

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Xie

Zhang

et al. 2014

Front. Bioeng. Biotechnol.

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Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70–80% suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50% for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired.

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Section: Discussionmentioning

confidence: 99%

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Xie

Zhang

et al. 2014

Front. Bioeng. Biotechnol.

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“…32 In our case, we are using 100 non-hallow MNs array with the area 0.25 cm 2 , which undergo the applied stress up to MNs breaking point by varying different concentration of GAPC into CS-CPL nanocomposite. 25,26,45 In the spectrum of GAPC (marked III), the peak value at 1732 cm −1 (C O) fits to the carboxylic groups tretching and peak value at 1630 cm −1 , was of characteristic O H bond of water molecule. Neat CS-CPL MNs film showed a tensile strength of $80 MPa.…”

Section: Mechanical Properties Of Cs-gapc-cpl Mns Conjugatesmentioning

confidence: 98%

Microneedles of chitosan‐porous carbon nanocomposites: Stimuli (pH and electric field)‐initiated drug delivery and toxicological studies

Gaware

Rokade

Bala

et al. 2019

J Biomedical Materials Res

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An array of microneedles (MNs) of chitosan‐graphene assembled in porous carbon (CS‐GAPC) nanocomposites has been synthesized and evaluated. The safety of the formulated system has been ensured using detailed in vivo toxicological studies and efficacy has been ensured by evaluating the stimuli (pH and electric field) initiated drug delivery properties. Drug cephalexin has been incorporated in these MNs. In vivo toxicological studies of CS‐GAPC nanocomposite were performed on Sprague rats, using acute dermal and subacute dermal (ADT& SADT) test, histopathological studies, biochemical studies, and AMES tests. ADT and SADT studies showed that median lethal dose (LD50) was found greater than 2000 mg/kg body weight; with no abnormal weight gain and food consumption, during the study period of 28 days. This study showed that administration of CS‐GAPC did not cause any substantial alterations in hematological and biochemical parameters of the animals. Histopathological studies showed no significant changes in the control and CS‐GAPC administered groups. AMES tests reveal that CS‐GAPC nanocomposite is nonmutagenic against the Salmonella thyphimurium strains. No abnormalities were observed in the animal's chromosomal aberrations and clastogenic values when the animals were treated with CS‐GAPC. At acidic pH of 4, the encapsulated drug was completely released, indicating that the drug release from the prepared nanocomposite is pH dependent. An electric field of 5 V showed optimum drug release, as a function of applied electric pulses. A biologically safe drug encapsulation model system is hence projected for smart drug delivery (pH dependent and electric field triggered) using the microneedle approach. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1582–1596, 2019.

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“…Both chitosan and chitin are used for solid wound dressings, and this is well documented. [67][68][69] For example, chitin-chitosan dual-layer materials have been prepared and used as solid wound dressing for the treatment of mustard burns.…”

Section: Natural Biopolymers As Hemostatic Agentsmentioning

confidence: 99%

Role of Polymeric Biomaterials as Wound Healing Agents

Agrawal

Soni

Mittal

et al. 2014

The International Journal of Lower Extremity Wounds

109

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In uncontrolled hemorrhage, the main cause of death on the battlefield and in accidents, half of the deaths are caused by severe blood loss. Polymeric biomaterials have great potential in the control of severe hemorrhage from trauma, which is the second leading cause of death in the civilian community following central nervous system injuries. The intent of this article is to provide a review on currently available biopolymers used as wound dressing agents and to describe their best use as it relates to the condition and type of the wound (acute, chronic, superficial, and full thickness) and the phases of the wound healing process. These biopolymers are beneficial in tissue engineering as scaffolds, hydrogels, and films. Different types of wound dressings based on biopolymers are available in the market, with various physical, chemical, and biological properties. The use of biopolymers as a hemostatic agent depends on its biocompatibility, biodegradability, nonimmunogenicity, and optimal mechanical property. This review summarizes different biopolymers, their physiological characters, and their use as wound healing agents along with biomedical applications.

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Wound dressing with sustained anti-microbial capability

Cited by 42 publications

References 0 publications

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Microneedles of chitosan‐porous carbon nanocomposites: Stimuli (pH and electric field)‐initiated drug delivery and toxicological studies

Role of Polymeric Biomaterials as Wound Healing Agents

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