Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

Moeini, Arash; Pedram, Parisa; Makvandi, Pooyan; Malinconico, Mario; d’Ayala, Giovanna Gomez

doi:10.1016/j.carbpol.2020.115839

Cited by 519 publications

(309 citation statements)

References 206 publications

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“…To these beneficial characteristics in the wound healing process is added its antimicrobial activity owing to the cationic nature of CS, which can determine the interaction between the negatively charged functional moieties situated on the surface of the bacteria’s cell wall and the –NH 3 + group. This interaction between differently charged groups can modify the bacterial surface morphology, which either can augment the membrane permeability, causing release of intracellular substances (nucleic acids, glucose, and proteins like lactate dehydrogenase), or it can diminish membrane permeability, hampering the nutrient transport [ 148 ].…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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“…Due to its biocompatibility, biodegradability, non-toxicity, and antimicrobial activity, chitosan is one of the most investigated biopolymers for wound healing [ 29 , 30 , 31 ]. A wide variety of biomedical applications have been reported for chitosan, especially for the treatment of cutaneous leishmaniasis.…”

Section: Activity Of Chitosan and Its Derivatives On Leimentioning

confidence: 99%

Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis

2020

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The control of leishmaniases, a complex parasitic disease caused by the protozoan parasite Leishmania, requires continuous innovation at the therapeutic and vaccination levels. Chitosan is a biocompatible polymer administrable via different routes and possessing numerous qualities to be used in the antileishmanial strategies. This review presents recent progress in chitosan research for antileishmanial applications. First data on the mechanism of action of chitosan revealed an optimal in vitro intrinsic activity at acidic pH, high-molecular-weight chitosan being the most efficient form, with an uptake by pinocytosis and an accumulation in the parasitophorous vacuole of Leishmania-infected macrophages. In addition, the immunomodulatory effect of chitosan is an added value both for the treatment of leishmaniasis and the development of innovative vaccines. The advances in chitosan chemistry allows pharmacomodulation on amine groups opening various opportunities for new polymers of different size, and physico-chemical properties adapted to the chosen routes of administration. Different formulations have been studied in experimental leishmaniasis models to cure visceral and cutaneous leishmaniasis, and chitosan can act as a booster through drug combinations with classical drugs, such as amphotericin B. The various architectural possibilities given by chitosan chemistry and pharmaceutical technology pave the way for promising further developments.

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“…Moreover, the ideal wound dressing should have good biocompatibility, hydrophilicity, mechanical strength, and appropriate antibacterial property to promote cell adhesion, proliferation, and differentiation [6,7]. Chitosan (CS), as a widely used natural polymer, has obtained great attention in skin tissue engineering [8]. It can promote the proliferation and differentiation of a broad spectrum of cells associated with wound healing, including keratinocytes, vascular endothelial cells, and fibroblasts.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound‐Healing Efficacy

Wang

et al. 2020

Advances in Materials Science and Engineering

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Chitosan (CS) is a natural polymer with applications in wound restorations and coatings for artificial implants. However, the lack of antimicrobial activity restricts its further application. Thus, the purpose of this study is to prepare CS/AuNPs film by adding gold nanoparticles (AuNPs) to modify chitosan. Through transmission electron microscopy, we found that the presence of CS can effectively prevent the agglomeration of nanoparticles. Furthermore, through the CCK experiment, we found that AuNPs at a certain concentration can improve the adhesion and proliferation of cells, which has also been proved in animal experiments, including gross appearance, histological observations, and immunofluorescence staining. Such findings support the feasibility of using the film as a promising candidate for tissue engineering of skin in a near future.

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Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

Cited by 519 publications

References 206 publications

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis

Evaluation of New Film Based on Chitosan/Gold Nanocomposites on Antibacterial Property and Wound‐Healing Efficacy

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