Wound Healing Process

Kordestani, Soheila S.

doi:10.1016/b978-0-323-67968-8.00003-3

Cited by 21 publications

(26 citation statements)

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“…It is a dynamic process due to the formation of a connective tissue matrix by collagen fibers synthesized after the migration of fibroblasts. 22 As fibroblasts differentiate to myofibroblasts, which are key players for retaining skin homeostasis and for arranging physiological tissue repair, the wound edges are drawn toward the center of the wound, which gradually reduces the wound area. 21,22 Compounds targeted to every phase of the wound healing process may be useful for the effective treatment of wounds.…”

Section: Discussionmentioning

confidence: 99%

“…22 As fibroblasts differentiate to myofibroblasts, which are key players for retaining skin homeostasis and for arranging physiological tissue repair, the wound edges are drawn toward the center of the wound, which gradually reduces the wound area. 21,22 Compounds targeted to every phase of the wound healing process may be useful for the effective treatment of wounds. 1,[23][24][25] Elements such as Zn, B, Mg, and iron (Fe) have an important role in the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

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The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

Gündoğdu

Nalcı

Kaplan

et al. 2020

The International Journal of Lower Extremity Wounds

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Wound healing remains a challenging clinical problem, especially in the presence of diabetes. Diabetic patients have the impaired ability to fight infection and insufficient inflammatory response. The aim of this study was to evaluate the effects of boronophenylalanine (BFA) and/or Zn-containing nanoemulsion (NE) formulations on wound healing in diabetic rats. MTT and scratch assays were performed to evaluate the proliferative effects of BFA and/or Zn on human dermal fibroblast (HDF) cells and the migration of these cells, respectively. The BFA and/or Zn-NE were prepared, and the effects of NEs on wound healing in diabetic rats were evaluated by applying once a day for 14 days. MTT assay showed that 10 to 25 µM BFA and/or 50 µM Zn had very significant positive effects on cell proliferation. In the scratch assay, 10 µM BFA significantly increased the migration of HDF cell compared with control. The droplet sizes of all the NEs were <115 nm and their zeta potential values were in range of (−) 23.9 ± 2.356 to (−) 33.1 ± 1.438 mV. There was a significant reduction in the wound contraction values (%) of the groups treated with the BFA and/or Zn-NE on the 14th day compared with the untreated diabetic rats group. According to histopathological findings, wound healing was nearly complete in BFA and/or Zn-NE compared with untreated diabetic rats. Especially, the group treated with the NE containing the low concentration of BFA showed highly promising results in wound healing of diabetic rats within 14 days with complete epithelialization and the completely closed wound area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

Gündoğdu

Nalcı

Kaplan

et al. 2020

The International Journal of Lower Extremity Wounds

View full text Add to dashboard Cite

show abstract

“…Secondly, inflammation occurs wherein immune cells infiltrate the scene, and numerous inflammatory cytokines, proteases, endopeptidases, and reactive oxygen species (ROS) are also present [14]. Neutrophils and macrophages are responsible for debridement.…”

Section: The Phases Of Wound Healingmentioning

confidence: 99%

Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair

et al. 2022

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Regenerative medicine is an active research sphere that focuses on the repair, regeneration, and replacement of damaged tissues and organs. A plethora of innovative wound dressings and skin substitutes have been developed to treat cutaneous wounds and are aimed at reducing the length or need for a hospital stay. The inception of biomaterials with the ability to interact with cells and direct them toward desired lineages has brought about innovative designs in wound healing and tissue engineering. This cellular engagement is achieved by cell cues that can be biochemical or biophysical in nature. In effect, these cues seep into innate repair pathways, cause downstream cell behaviours and, ultimately, lead to advantageous healing. This review will focus on biomolecules with encoded biomimetic, instructive prompts that elicit desired cellular domino effects to achieve advanced wound repair. The wound healing dressings covered in this review are based on functionalized biopolymeric materials. While both biophysical and biochemical cues are vital for advanced wound healing applications, focus will be placed on biochemical cues and in vivo or clinical trial applications. The biochemical cues aforementioned will include peptide therapy, collagen matrices, cell-based therapy, decellularized matrices, platelet-rich plasma, and biometals.

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“…The purpose of skeletal muscle tissue engineering is to replicate the natural structure and function of muscle in vitro and to transplant this tissue to the damaged area, Skin healing process and mechanism using the nanocomposite wound dressing [97].…”

Section: Skeletal Muscle Tissue Engineeringmentioning

confidence: 99%

Nanocomposite Biomaterials for Tissue Engineering and Regenerative Medicine Applications

Liu¹,

Lin²,

Pu³

et al. 2022

Nanocomposite Materials for Biomedical and Energy Storage Applications

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Nanocomposites are materials that are usually created by introducing appropriate nanoparticles into a macroscopic matrix, enabling the resulting bulk nanocomposites remarkable characteristics in electrical, thermal conductivity, mechanical, optical, magnetic properties, and so on. Such nanocomposite materials are of great importance for biomedical applications, particularly promising for tissue engineering scaffolds. Recent trends in the nanocomposites field show bio-based/environmentally friendly materials to be among the components in these nanocomposite materials. Particular attention has been paid to the use of bio-based/biodegradable polymers as a matrix component in nanocomposite applications, because of their great widespread potential and advantages over other traditional synthetic materials. In this chapter, we focus on the current research trends of the tissue engineering scaffolds based on nanocomposite materials and mainly introduce the properties, types, manufacturing techniques, and tissue engineering applications of various nanocomposite biomaterials. Besides, challenges and prospects associated with nanocomposite biomaterials for the tissue engineering field were discussed. We believe that this chapter provides a new envision for building functional nanocomposite materials for broad biomedical applications.

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Wound Healing Process

Cited by 21 publications

References 0 publications

The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair

Nanocomposite Biomaterials for Tissue Engineering and Regenerative Medicine Applications

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