Wound Healing Update

Morton, Laurel M.; Phillips, Tania J.

doi:10.1016/j.sder.2011.11.007

Cited by 45 publications

(24 citation statements)

References 58 publications

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“…However, in recent decades wound treatment has been revolutionized by the discovery that moist dressings can help wounds heal faster [67,68]. Furthermore, a moist wound environment is also an important factor to induce the proliferation and migration of fibroblasts and keratinocytes as well as to enhance collagen synthesis, leading to reduced scar formation [69,70].…”

Section: Types and Main Characteristics Of Wound Dressingsmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

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Section: Types and Main Characteristics Of Wound Dressingsmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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“…In complex clinical environments, wound surfaces are highly prone to bacterial infections, which affects the healing of wound surfaces [2, 3]. When wounds are infected, especially by drug-resistant bacteria, we face enormous challenges in clinical practice [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial constituents of Fructus Chebulae Immaturus and their mechanisms of action

Lin

et al. 2016

BMC Complement Altern Med

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BackgroundTo extract, purify, and identify the effective constituents of aqueous extract of Fructus Chebulae Immaturus, and analyze the bactericidal effects of total tannins.MethodsPreparative thin layer chromatography and semi-preparative high performance liquid chromatography were used to isolate and purify the total tannin fraction. 1H- and 13C- NMR spectroscopy were used to elucidate compound structures. The antibacterial activities of total tannins and ethyl gallate on Klebsiella pneumoniae (KP) and Staphylococcus aureus (SA) were determined through minimum inhibitory concentration and minimum bactericidal concentration assays. Their antibacterial mechanisms of action were explored by transmission electron microscopy and scanning electron microscopy.ResultsFive compounds were isolated: ellagic acid, ethyl gallate, arjugenin, β-sitosterol, and tri-n-butyl chebulate. Tri-n-butyl chebulate is a newly-reported compound. Total tannins and ethyl gallate both had favorable bactericidal effects against KP and SA.ConclusionIn vivo and in vitro pharmacodynamic experiment demonstrated that the effective components of Fructus Chebulae Immaturus possessed significant antibacterial effects, and were nontoxic and safe.Trial registrationNo results of a health care intervention on human participants

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“…The rats were anesthetized once intraperitoneally with ketamine HCl (50 mg/kg) and xylazine (5 mg/kg) [10] in accordance with the protocol approved by the animal care and use committee and prepared for surgery. Circular wounds were made in three layers of skin with 10 mm diameter in all three layers (dermis, epidermis, and hypodermis …”

Section: Animals and Study Designmentioning

confidence: 99%

“…Collagen confession phase begins immediately and lasts for months. In this phase, collagen synthesis begins by fibroblasts and done stimulation of macrophages [8][9][10][11][12]. Inflammation maintenance and scarce vessel formation comprise the most noticeable causes of delayed wound healing [13].…”

Section: Introductionmentioning

confidence: 99%

Wound Healing Effect of Satureja Khuzistanica and Satureja Rechingeri Ethanolic Extracts in NMRI Adult Mice

Sahraei

Gharzi

Amiri

et al. 2016

Zahedan J Res Med Sci

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Wound Healing Update

Abstract: The management of acute and chronic wounds has drastically changed within the past 20 years. This update focuses on the most recent recommendations for acute wound care as well as new technologies that are available for chronic wounds.

Cited by 45 publications

References 58 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Antibacterial constituents of Fructus Chebulae Immaturus and their mechanisms of action

Wound Healing Effect of Satureja Khuzistanica and Satureja Rechingeri Ethanolic Extracts in NMRI Adult Mice

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