2023
DOI: 10.3389/fendo.2023.1234569
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Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Giusy Di Conza,
Fulvio Barbaro,
Nicoletta Zini
et al.

Abstract: BackgroundDisordered and hypomineralized woven bone formation by dysfunctional mesenchymal stromal cells (MSCs) characterize delayed fracture healing and endocrine –metabolic bone disorders like fibrous dysplasia and Paget disease of bone. To shed light on molecular players in osteoblast differentiation, woven bone formation, and mineralization by MSCs we looked at the intermediate filament desmin (DES) during the skeletogenic commitment of rat bone marrow MSCs (rBMSCs), where its bone-related action remains e… Show more

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Cited by 3 publications
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“…Intracellular proteins like desmin, alpha-smooth muscle actin (α-SMA), regulator of G protein signaling 5 (RGS-5), cell surface proteins like neuron-glial antigen 2 (NG2), and platelet-derived growth factor receptor beta (PDGFR-β) are the main target molecules used commonly for pericyte identification ( van Splunder et al, 2023 ). Unfortunately, desmin belonging to type III contractile filaments can be found in different muscle cell types ( Di Conza et al, 2023 ). Likewise, α-SMA is a cytoskeletal protein and presents in smooth-muscle cells and fibroblasts ( Zheng et al, 2023 ).…”
Section: Pericytes Function and Activitymentioning
confidence: 99%
“…Intracellular proteins like desmin, alpha-smooth muscle actin (α-SMA), regulator of G protein signaling 5 (RGS-5), cell surface proteins like neuron-glial antigen 2 (NG2), and platelet-derived growth factor receptor beta (PDGFR-β) are the main target molecules used commonly for pericyte identification ( van Splunder et al, 2023 ). Unfortunately, desmin belonging to type III contractile filaments can be found in different muscle cell types ( Di Conza et al, 2023 ). Likewise, α-SMA is a cytoskeletal protein and presents in smooth-muscle cells and fibroblasts ( Zheng et al, 2023 ).…”
Section: Pericytes Function and Activitymentioning
confidence: 99%