Wrinkles and Acne Scars: Technology-Based Treatment of Periorbital Wrinkles

Efficacy and safety evaluation of an innovative CO2 laser/radiofrequency device in dermatology

“…After this first phase there is a proliferative phase with the recruitment of fibroblasts and deposition of new type‐III collagen fibres and dermal matrix; the last phase is characterized by collagen remodelling, when the thinner type‐III collagen fibres are replaced by type‐I collagen fibres 33–38 . The laser system (SmartXide 2 DOT/RF) we used in this study simultaneously delivers laser and bipolar radiofrequency; the latter is able to amplify and enhance the effects of the CO 2 laser by remodelling the tissue in‐depth, toning flabbiness and stimulating fibroblast activity to produce new collagen 21–28 . Previous histological studies have in fact confirmed the presence of thickened, shortened collagen fibrils after bipolar radiofrequency treatments and an increased collagen‐I upregulation has been observed through the northern blot analysis 26 .…”

“…The recovery times were between 3 and 7 days in nearly all patients, and the erythema usually never lasted longer than 7 days, showing a reduction in superficial hyperaemia. The average downtime for the fractional CO 2 laser/bipolar radiofrequency device in group B was 5.4 days, showing a slight reduction compared with previous results using fractional CO 2 laser alone 20–39 . Faster healing allowed patients to return to a normal life in public within the first week after the laser session, as there were no marked side‐effects to hide or tolerate.…”

“…[33][34][35][36][37][38] The laser system (SmartXide 2 DOT ⁄ RF) we used in this study simultaneously delivers laser and bipolar radiofrequency; the latter is able to amplify and enhance the effects of the CO 2 laser by remodelling the tissue in-depth, toning flabbiness and stimulating fibroblast activity to produce new collagen. [21][22][23][24][25][26][27][28] Previous histological studies have in fact confirmed the presence of thickened, shortened collagen fibrils after bipolar radiofrequency treatments and an increased collagen-I upregulation has been observed through the northern blot analysis. 26 It has therefore been demonstrated how fractional CO 2 laser and radiofrequency are able to induce similar histological modifications in the superficial layers of the skin.…”

“…With this strategy, more effective and varied biological effects can be induced in the tissue, stimulating the dermis to produce new collagen, naturally regenerating the texture and enhancing skin tone and softness 20 . For the last 5 years, bipolar radiofrequency devices have been considered non‐invasive instruments, able to stimulate the deeper dermis in a non‐ablative manner 21–28 . Nowadays, only a few devices combine the effect of radiofrequency with laser or light energy in a unique tool capable of targeting lesions requiring surgical ablation, as well as aesthetical imperfections such as fine lines, wrinkles, pigment alterations, and skin laxity that have to be reduced or completely removed.…”

“…20 For the last 5 years, bipolar radiofrequency devices have been considered noninvasive instruments, able to stimulate the deeper dermis in a non-ablative manner. [21][22][23][24][25][26][27][28] Nowadays, only a few devices combine the effect of radiofrequency with laser or light energy in a unique tool capable of targeting lesions requiring surgical ablation, as well as aesthetical imperfections such as fine lines, wrinkles, pigment alterations, and skin laxity that have to be reduced or completely removed. The purpose of our study is to examine the efficacy and safety of this novel device combining fractional CO 2 laser and ra-diofrequency in different fields of dermatological, surgical and aesthetic treatment.…”