WU Polyomavirus Infection Confirmed by Genetic and Serologic Tests in an Infant With Bronchitis

Teramoto, Shinobu; Koseki, Naoko; Yoshioka, Masaharu; Matsunami, Yukiko; Yanazume, Noriko; Nawate, Mitsuru; Shikano, Takaaki; Takahashi, Yutaka; Kikuta, Hídeaki; Ishiguro, Nobuhisa

doi:10.1097/inf.0b013e3182252148

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…Karolinska Institutet Polyomavirus (KIPyV) and Washington University Polyomavirus (WUPyV) were discovered in 2007 in nasopharyngeal samples from patients with respiratory symptoms [7,8]. So far, whether KIPyV and WUPyV are genuine respiratory pathogens or opportunistic co-infectors has not been established, although KIPyV transcripts were identified without other viral sequences in cases of otherwise healthy individuals with severe respiratory symptoms and WUPyV sequences were found in WUPyV-associated bronchitis [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients

et al. 2021

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Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 healthcare workers not infected by SARS-CoV-2, were collected from March 2020 through May 2020 and tested for KIPyV and WUPyV DNA presence. Of the 112 SARS-CoV-2 positive patients, 27 (24.1%) were co-infected with KIPyV, 5 (4.5%) were positive for WUPyV, and 3 (2.7%) were infected simultaneously by KIPyV and WUPyV. Neither KIPyV nor WUPyV DNA was detected in samples of healthcare workers. Significant correlations were found in patients co-infected with SARS-CoV-2 and KIPyV (p < 0.05) and between SARS-CoV-2 cycle threshold values and KIPyV, WUPyV and KIPyV and WUPyV concurrently detected (p < 0.05). These results suggest that KIPyV and WUPyV may behave as opportunistic respiratory pathogens. Additional investigations are needed to understand the epidemiology and the prevalence of respiratory polyomavirus in COVID-19 patients and whether KIPyV and WUPyV could potentially drive viral interference or influence disease outcomes by upregulating SARS-CoV-2 replicative potential.

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