Wulff-type boronic acid-functionalized quantum dots for rapid and sensitive detection of Gram-negative bacteria

Nano-based theranostic approaches for infection control: current status and perspectives

“…65,66 In another study, Wulff-type boronic acid-functionalized quantum dots developed by Ye and co-workers can selectively target E. coli over a wide range of pH. 67 Similarly, poly(amidoamine) (PAMAM), a chemically modified dendrimer with five phenylboronic acid groups at the terminus, demonstrates a promising ability to recognize GÀ bacteria. 68 While most boronic acid-based probes have shown great potential in targeting the LPS on the membrane surface of GÀ bacteria, they can also be used for detecting G+ bacterial cells.…”

A metal–organic framework-based fluorescence resonance energy transfer nanoprobe for highly selective detection of Staphylococcus Aureus

“…The limit of detection (LOD) is calculated to be 12 CFU mL À1 , which is comparable to previously reported fluorescent probes for bacteria detection. [38][39][40][41][42] The LOD was calculated using the equation: LOD = 3s/k, where s is the standard deviation of 11 data for the blank sample, and k is the slope. These results demonstrate the suitability of our FRET nanoprobe for the quantitative detection of S. aureus.…”

Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels

“…For example, glucose can induce the aggregation of boronic acid-modified carbon dots (CDs), leading to fluorescence quenching [ 164 , 165 , 166 ]. Ye et al reported an aggregated-induced fluorescence “turn-off” bioassay of Gram-negative bacteria using Wulff-type boronic acid-modified QDs [ 167 ]. As shown in Figure 8 , Wulff-type L-cysteine (Cys)-APBA consisting of an amine adjacent to the boronic acid group was used to modify QDs (QDs/Cys-APBA), lowering the pKa value and stabilizing the boronic ester in neutral pH medium.…”