Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp

Fu, Ruonong; Wang, Xiaonan; Guo, Chao; Liu, Ying; Ding, Cong-Yang; Dong, Zhanjun

doi:10.21037/atm-21-1303

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…It was found that when both substances were administered simultaneously, Wuzhi capsule decreased CLz/F and Vz/F of methotrexate and increased Cmax. In addition, the administration of S. sphenanthera extract inhibited the expression of OAT1/3 proteins in the kidneys and P-gp in the small intestine, which may suggest the future use of this combination to reduce inflammation when administering immunosuppressive drugs [ 152 ]. The latest research shows that in the future, the combination of the Wuzhi capsule with anti-cancer drugs will be widely available and recommended.…”

Section: Dbcls As Potential Chemotherapeutic Adjuvantsmentioning

confidence: 99%

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Jafernik,

Motyka,

Calina

et al. 2024

Chin Med

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Cancer remains one of the leading causes of mortality worldwide. The search for novel and effective anticancer agents has been a significant area of research. Dibenzocyclooctadiene lignans (DBCLS), derived from the Schisandra genus plants like: S. chinensis, S. sphenanthera, S. henryi, S. rubriflora, S. grandiflora, S. propinqua, and S. glabra, have been traditionally used in various medicinal systems and are known for their myriad health benefits, including anticancer properties. This comprehensive review aimed to collate and critically analyse the recent literature on the anticancer properties of DBCLS, focusing on their mechanistic approaches against different cancer types. An exhaustive literature search was performed using databases like PubMed/MedLine, Scopus, Web of Science, Embase, TRIP database and Google Scholar from 1980 to 2023. Peer-reviewed articles that elucidated the mechanistic approach of these lignans on cancer cell lines, in vivo models and preliminary clinical studies were included. Studies were assessed for their experimental designs, cancer types studied, and the mechanistic insights provided. The studies demonstrate that the anticancer effects of DBCLS compounds are primarily driven by their ability to trigger apoptosis, arrest the cell cycle, induce oxidative stress, modulate autophagy, and disrupt essential signaling pathways, notably MAPK, PI3K/Akt, and NF-κB. Additionally, these lignans have been shown to amplify the impact of traditional chemotherapy treatments, suggesting their potential role as supportive adjuncts in cancer therapy. Notably, several studies also emphasise their capacity to target cancer stem cells and mitigate multi-drug resistance specifically. DBCLS from the Schisandra genus have showcased significant potential as anticancer agents. Their multi-targeted mechanistic approach makes them promising candidates for further research, potentially leading to developing of new therapeutic strategies in cancer management.

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Section: Dbcls As Potential Chemotherapeutic Adjuvantsmentioning

confidence: 99%

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Jafernik,

Motyka,

Calina

et al. 2024

Chin Med

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“…Organic anion transporter 3 (OAT3) is an important transporter that located in the basolateral membrane of proximal renal tubules. OAT3 plays vital parts in removing a variety of drugs from the kidney, so as to avoid their possibly toxic side effects in the body (Fu et al, 2021). Activated OAT3 attenuates renal lipid accumulation and alleviates renal injury associated with renal inflammation and fibrosis in high-fat diet-induced obese rats (Pengrattanachot et al, 2020).…”

Section: Oat3-mediated Transfer Channelsmentioning

confidence: 99%

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

et al. 2022

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Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development of renal fibrosis. Recent advances suggest that SUMOylation functions as the promising intervening target against renal fibrosis, and natural products prevent renal fibrosis via modulating SUMOylation. Here, we introduce the mechanism of SUMOylation in renal fibrosis and therapeutic effects of natural products. This process starts by summarizing the key mediators and enzymes during SUMOylation and deSUMOylation and its regulation role in transcriptional factors and key mediators in renal fibrosis, then linking the mechanism findings of SUMOylation and natural products to develop novel therapeutic candidates for treating renal fibrosis, and concludes by commenting on promising therapeutic targets and candidate natural products in renal fibrosis via modulating SUMOylation, which highlights modulating SUMOylation as a promising strategy for natural products against renal fibrosis.

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P‐glycoprotein‐mediated herb–drug interaction evaluation between Tenacissoside G and paclitaxel

Hu,

et al. 2024

Biomedical Chromatography

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P‐glycoprotein (P‐gp)‐mediated herb–drug interactions (HDIs) may impact drug efficacy and safety. Tenacissoside G (Tsd‐G), a major active component of Marsdenia tenacissima, exhibits anticancer activity. To analyze the effect of Tsd‐G on the pharmacokinetics of paclitaxel (PTX), researchers selected 30 Sprague–Dawley (SD) rats, randomized into a solvent control group, a verapamil positive control group, and 20, 40, and 60 mg/kg Tsd‐G groups. After seven consecutive days of intraperitoneal injection of verapamil or Tsd‐G, a single dose of 6 mg/kg PTX was injected intravenously. Plasma samples were collected at different time points, and proteins were precipitated using a methanol–acetonitrile solution. An ultrahigh‐performance liquid chromatography–tandem mass spectrometry method was developed, with docetaxel as an internal standard, and quantified using positive ion multiple reaction monitoring (MRM) mode. This analytical method's specificity, accuracy, precision, recovery, matrix effect, and sample stability meet the requirements for biological sample determination. After Tsd‐G administration in rats, the mean residence time of PTX was significantly prolonged. And Tsd‐G can stably bind to P‐gp by forming hydrogen bonds and inhibiting the expression of P‐gp in rat liver. Although the metabolites of PTX were not detected in this study, the above results still indicate the existence of HDIs between Tsd‐G and PTX, and P‐gp may be the main target to mediate HDIs.

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Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp

Cited by 7 publications

References 33 publications

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

P‐glycoprotein‐mediated herb–drug interaction evaluation between Tenacissoside G and paclitaxel

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