X-ray grating interferometry for 9.25 keV design energy at a liquid-metal-jet source

Balles, Andreas; Fella, Ch.; Dittmann, Jonas; Wiest, Wolfram; Zabler, Simon; Hanke, Randolf

doi:10.1063/1.4937537

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…In the last years, the single-grating approach has seen increasing interest and a number of setups have been reported in the literature using either a single phase or absorption grating to create an interference pattern combined with a phase-stepping scan Balles et al, 2016;Schulz et al, 2017b;Balles et al, 2018;Yang et al, 2019]. Experimental implementations of single-shot single-grating measurements for high-speed imaging have been proposed using 1D and 2D…”

Section: Grating Interferometry Without Absorption Grating G2mentioning

confidence: 99%

“…All of the above results were obtained with X-ray beams of sufficient spatial coherence to observe the self-image of the G1 phase grating without G0. This is the case for synchrotron sources, but also achievable at high-end laboratory sources such as the liquid-metal-jet source (see Chapter 2, Section 2.6.1), for which a single-grating setup has been demonstrated as well [Balles et al, 2016[Balles et al, , 2018. Moreover, analogous to the classic Talbot-Lau interferometer with three gratings, a G2-less setup can also be realised at conventional tube source with low spatial coherence by adding a source grating G0.…”

Section: Grating Interferometry Without Absorption Grating G2mentioning

confidence: 99%

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X-ray Phase-Contrast Imaging Using Near-Field Speckles

Zdora¹

2021

Springer Theses

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In the last decades, X-ray phase-contrast imaging has proven to be a powerful method for unveiling the inner structure of samples and is capable of visualising even minute density differences. Recently, speckle-based imaging (SBI), the youngest X-ray phase-sensitive technique, has received great interest due to its high sensitivity, quantitative character and relaxed requirements on the setup components and beam properties. This thesis is focussed on the development, experimental optimisation and applications of SBI, with the aim of simplifying its implementation, increasing its flexibility and expanding its potential.For this, a robust, flexible data acquisition and reconstruction approach, the unified modulated pattern analysis (UMPA), was developed, which lifts previous constraints of SBI. UMPA allows for tuning of the sensitivity and spatial resolution by adjusting the scan and reconstruction parameters. It is applicable not only to random speckle, but also periodic interference patterns, bridging the gap and improving the performance of both speckle-and single-grating-based techniques.Following the first demonstration of UMPA, its potential for a range of applications is illustrated in this thesis. It is shown that UMPA can be employed for X-ray optics characterisation to quantify aberrations in the focussing behaviour of X-ray refractive lenses with high precision and accuracy. UMPA phase tomography is applied to the field of biomedical imaging for high-sensitivity three-dimensional (3D) virtual histology of unstained, hydrated soft tissue, giving unprecedented structural and quantitative density information.Further developments of SBI explored in this thesis include the testing of novel customisable speckle diffusers, the extension of SBI to higher X-ray energies for geology and materials science applications, and the demonstration of UMPA at a laboratory X-ray source. These progresses promise new possibilities of SBI for high-sensitivity, robust and high-throughput imaging in previously inaccessible fields and make SBI accessible to a wider range of users in research and industry.

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Section: Grating Interferometry Without Absorption Grating G2mentioning

confidence: 99%

Section: Grating Interferometry Without Absorption Grating G2mentioning

confidence: 99%

X-ray Phase-Contrast Imaging Using Near-Field Speckles

Zdora¹

2021

Springer Theses

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“…The conventional implementations of XGI at synchrotrons use a setup with a beam-splitter phase grating and an absorption grating that converts the high-frequency interference pattern into intensity modulations in the detector pixels while one of the gratings is stepped perpendicular to the grating lines, known as phase-stepping scan. A simpler and more robust setup can be achieved with the use of only a single phase grating, which has been reported for single-shot measurements with 2D and 1D gratings [ 29 – 31 ]. Recently, a setup using the phase-stepping approach with a single line grating has been proposed allowing more dose- and time-efficient imaging with a simple arrangement albeit a decreased spatial resolution [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue

Zdora¹,

Vila‐Comamala²,

Schulz³

et al. 2017

Biomed. Opt. Express

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The high-throughput 3D visualisation of biological specimens is essential for studying diseases and developmental disorders. It requires imaging methods that deliver high-contrast, high-resolution volumetric information at short sample preparation and acquisition times. Here we show that X-ray phase-contrast tomography using a single grating can provide a powerful alternative to commonly employed techniques, such as high-resolution episcopic microscopy (HREM). We present the phase tomography of a mouse embryo in paraffin obtained with an X-ray single-grating interferometer at I13-2 Beamline at Diamond Light Source and discuss the results in comparison with HREM measurements. The excellent contrast and quantitative density information achieved non-destructively and without staining using a simple, robust setup make X-ray single-grating interferometry an optimum candidate for high-throughput imaging of biological specimens as an alternative for existing methods like HREM.

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“…径的探索中, Endrizzi等 [4] 、Fu等 [5] 、Wei等 [6] 以及Ge等 [7] [8] 、 Marathe [9] 以及 Wen [10] 、Bennett [11] 等验证了第二种途径的可行性, 此后基于免分析光栅X射线相位衬度成像系统的一次曝光成像理论的发展受到了广泛的关注. 但是目前基于该成像理论的样品信息提取算法还不完善.…”

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Method of single exposure phase contrast imaging without analyser grating

Chun-Xia¹,

He²,

Zhang³

et al. 2021

Acta Phys. Sin.

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X-ray differential phase contrast imaging technology can reveal the weakly absorbing fine structure which cannot be observed by the conventional X-ray absorption contrast imaging. Hence, it has potential applications in many fields such as medical science, and material science. But in the traditional X-ray grating differential phase contrast imaging system, the analyser grating is used as a spatial filter, and needs to be phase stepped, then multiple exposures are required for information extraction. Thus this leads to high-dose radiation exposure and low efficiency of X-ray utilization. All these disadvantages limit its application in various disciplines. In order to cope with the above issues, a new algorithm based on single-shot grating differential phase contrast imaging system without analyzer grating is proposed. In such a system the absorption, refraction and scattering information can be obtained from one projective image of the sample acquired by a high-resolution detector. The reliability of this new algorithm is confirmed by numerical simulation. Compared with the phase stepping algorithm, the proposed algorithm can provide very accurate and reliable information extraction results without requiring the grating period to match with detector pixel size. It facilitates the reduction of the radiation damage to sample. We emphasize that this method is highly compatible with the future X-ray phase contrast imaging clinical applications.

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X-ray grating interferometry for 9.25 keV design energy at a liquid-metal-jet source

Cited by 9 publications

References 16 publications

X-ray Phase-Contrast Imaging Using Near-Field Speckles

X-ray Phase-Contrast Imaging Using Near-Field Speckles

X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue

Method of single exposure phase contrast imaging without analyser grating

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