X-ray visible microspheres derived from highly branched biodegradable poly(lactic acid) terminated by triiodobenzoic acid: Preparation and degradation behavior

Wang, Wenhuan; Sang, Lin; Guan, Qingbo; Zhao, Yiping; Wei, Zhiyong; Li, Yang

doi:10.1016/j.polymdegradstab.2020.109149

Cited by 4 publications

(1 citation statement)

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“…concern is that the entrapped contrast materials have the possibility of leaching out from the hydrogels over long-term embolization, which may compromise the radiopacity or have detrimental effects on the surrounding tissue. The intrinsically radiopaque embolic agents have been explored by covalently conjugating the iodine-containing species onto the polymers, [187,188] which have demonstrated their good biocompatibility and sufficient X-ray radiopacity. In terms of the hydrogel-based embolic agents, some attempts have been carried out to synthesize iodinated hydrogels to impart radiopacity.…”

Section: Conjugation Of Iodinated Species On Hydrogelsmentioning

confidence: 99%

Recent Progress in Advanced Hydrogel‐Based Embolic Agents: From Rational Design Strategies to Improved Endovascular Embolization

Ullah

et al. 2023

Adv Healthcare Materials

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Transcatheter arterial embolization, a minimally invasive treatment to deliberately occlude the blood vessels, has become a safe and effective procedure for the management of vascular diseases and benign/malignant tumors. Particularly, hydrogel‐based embolic agents have garnered much attention because of their potential to address some of the limitations of clinically used embolic agents and can be rationally designed to impart more favorable characteristics or functions. In this review, the recent progress toward the development of polymer‐based hydrogels for effective endovascular embolization, including the in situ gelling hydrogels mediated by physically or chemically crosslinking, imageable hydrogels for intraprocedural and postprocedural feedback, use of hydrogels as the drug depot for local delivery of therapeutic drugs, hemostatic hydrogels inducing extrinsic or intrinsic coagulation of blood, stimuli‐responsive shape memory hydrogels as the smart embolization devices, and hydrogels incorporating external‐stimuli functional materials for multidisciplinary therapy, is systemically summarized. Moreover, the potential considerations of hydrogel‐based embolic agents confronted in therapeutic embolization are pointed out. Finally, the perspectives for the development of more effective embolic hydrogels are also highlighted.

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Section: Conjugation Of Iodinated Species On Hydrogelsmentioning

confidence: 99%