X-Tream: a novel dosimetry system for Synchrotron Microbeam Radiation Therapy

Petasecca, Marco; Cullen, Ashley; Fuduli, Iolanda; Espinoza, Anthony A; Porumb, C.; Stanton, C. J.; Aldosari, A. H.; Bräuer-Krisch, Elke; Requardt, H.; Bravin, A.; Perevertaylo, Vladimir; Rosenfeld, Anatoly B.; Lerch, Michael L. F

doi:10.1088/1748-0221/7/07/p07022

Cited by 42 publications

(45 citation statements)

References 16 publications

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“…The “drop‐in” technology is compatible with standard flexible printed circuit manufacturing technologies and avoids the use of high atomic number materials for packaging of semiconductor radiation detectors, minimizing the perturbation of the beam. The kapton pigtail outside of the diode is shielded by a thin aluminum foil and grounded to minimize radiofrequency interference . Further details on the “drop‐in” packaging technology can be found elsewhere …”

Section: Methodsmentioning

confidence: 99%

Development of a silicon diode detector for skin dosimetry in radiotherapy

et al. 2017

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Purpose: The aim of in vivo skin dosimetry was to measure the absorbed dose to the skin during radiotherapy, when treatment planning calculations cannot be relied on. It is of particularly importance in hypo-fractionated stereotactic modalities, where excessive dose can lead to severe skin toxicity. Currently, commercial diodes for such applications are with water equivalent depths ranging from 0.5 to 0.8 mm. In this study, we investigate a new detector for skin dosimetry based on a silicon epitaxial diode, referred to as the skin diode. Method: The skin diode is manufactured on a thin epitaxial layer and packaged using the "drop-in" technology. It was characterized in terms of percentage depth dose, dose linearity, and dose rate dependence, and benchmarked against the Attix ionization chamber. The response of the skin diode in the build-up region of the percentage depth dose (PDD) curve of a 6 MV clinical photon beam was investigated. Geant4 radiation transport simulations were used to model the PDD in order to estimate the water equivalent measurement depth (WED) of the skin diode. Measured output factors using the skin diode were compared with the MOSkin detector and EBT3 film at 10 cm depth and at surface at isocenter of a water equivalent phantom. The intrinsic angular response of the skin diode was also quantified in charge particle equilibrium conditions (CPE) and at the surface of a solid water phantom. Finally, the radiation hardness of the skin diode up to an accumulated dose of 80 kGy using photons from a Co-60 gamma source was evaluated. Results: The PDD curve measured with the skin diode was within 0.5% agreement of the equivalent Geant4 simulated curve. When placed at the phantom surface, the WED of the skin diode was estimated to be 0.075 AE 0.005 mm from Geant4 simulations and was confirmed using the response of a corrected Attix ionization chamber placed at water equivalent depth of 0.075 mm, with the measurement agreement to within 0.3%. The output factor measurements at 10 cm depth were within 2% of those measured with film and the MOSkin detector down to a field size of 2 9 2 cm 2 . The dose-response for all detector samples was linear and with a repeatability within 0.2%. The skin diode intrinsic angular response showed a maximum deviation of 8% at 90 degrees and from 0 to 60 degree is less than 5%. The radiation sensitivity reduced by 25% after an accumulated dose of 20 kGy but after was found to stabilize. At 60 kGy total accumulated dose the response was within 2% of that measured at 20 kGy total accumulated dose. Conclusions: This work characterizes an innovative detector for in vivo and real-time skin dose measurements that is based on an epitaxial silicon diode combined with the Centre for Medical Radiation Physics (CMRP) "drop-in" packaging technology. The skin diode proved to have a water equivalent depth of measurement of 0.075 AE 0.005 mm and the ability to measure doses accurately relative to reference detectors.

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Section: Methodsmentioning

confidence: 99%

Development of a silicon diode detector for skin dosimetry in radiotherapy

et al. 2017

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“…Dosimetry of broad beams was performed using a pinpoint chamber TW31014 with a sensitive volume of 0.015 cm 3 . The dose measurements are corrected for ion recombination effects applying a so called "ramping-method."…”

Section: A Absolute Dose Calibration Of Films With Ionization Chammentioning

confidence: 99%

“…In recent years, silicon detectors have become very accurate, though, showing a high resolution, linearity over a wide dose range and allow a microsecond real-time readout. 3,4 However, solid state detectors are usually not water equivalent and may induce distortions in the radiation field. Other more tissue equivalent detectors are MRI gel dosimeters (e.g., PRESAGE™).…”

Section: Introductionmentioning

confidence: 99%

Micrometer‐resolved film dosimetry using a microscope in microbeam radiation therapy

et al. 2015

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Both film types are appropriate for dosimetry in MRT and the microscope is superior to the microdensitometer used before at the ESRF with respect to resolution and reproducibility. However, a very careful analysis of the image data is required. Dosimetry at low photon energies should be performed with great caution due to the energy sensitivity of the films. In this respect, HD-V2 films showed to have an advantage over HD-810 films. However, HD-810 films have a lower statistical noise level. When a higher resolution is required, e.g., for the dosimetry of pencil beam irradiations, noise may render HD-V2 films inapplicable.

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“…26 Similarly, researchers have used a plastic scintillator based fiber-optic dosimeter for translational movement with a stepper motor and drive screw as a device to acquire the 1D lateral dose profile of a 10 × 10 cm electron beam at a resolution of 3.9 mm. 27 However, for microbeam measurements in which the overall lateral beam dimension is less than 1 mm, a smaller optical fiber based point detector is required to achieve the necessary spatial resolution.…”

Section: C Translation Technique For Measuring 1d Profilesmentioning

confidence: 99%

Fiber‐optic detector for real time dosimetry of a micro‐planar x‐ray beam

et al. 2015

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Purpose:Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle‐terminated fiber‐optic dosimeter (nano‐FOD).Methods:The nano‐FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x‐ray microbeam.Results:The continuous dose rate at the x‐ray microbeam peak measured with the nano‐FOD was 1.91 ± 0.06 cGy s−1, a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s−1). The nano‐FOD‐determined lateral beam full‐width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm).Conclusions:This work provides proof‐of‐concept data and demonstrates that the novel nano‐FOD device can be used to perform real‐time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x‐ray microbeam peak as well as the lateral beam shape.

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X-Tream: a novel dosimetry system for Synchrotron Microbeam Radiation Therapy

Cited by 42 publications

References 16 publications

Development of a silicon diode detector for skin dosimetry in radiotherapy

Development of a silicon diode detector for skin dosimetry in radiotherapy

Micrometer‐resolved film dosimetry using a microscope in microbeam radiation therapy

Fiber‐optic detector for real time dosimetry of a micro‐planar x‐ray beam

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