Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent

Jahaniani, Fereshteh; Ebrahimi, Soltan Ahmad; Rahbar‐Roshandel, Nahid; Mahmoudian, Massoud

doi:10.1016/j.phytochem.2005.04.035

Cited by 138 publications

(107 citation statements)

References 25 publications

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“…The propagation D. kotschyi by seed is restricted because of strong seed dormancy. In traditional medicine, D. kotschyi is used for stomach and liver disorders because of its antispasmodic and analgesic properties (Jahaniani et al 2005). It is also used for its antihyperlipidermic effects and immune modulatory effects (on rheumatoid arthritis) (Amirghofran et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…This plant inhibits the multiplication of tumor cells; thus it has been used in the development of drugs effective against cancer (Cordell et al 1991). An anticancer drug (Spinal-Z) introduced by Iranian researchers, which has a specific effect against leukemia, is extracted from D. kotschyi leaves and Peganum harmala seeds (Sobhani et al 2002;Jahaniani et al 2005).…”

Section: Introductionmentioning

confidence: 99%

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Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Sharafi

Sohi

Azadi

et al. 2014

Physiol Mol Biol Plants

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An efficient hairy root induction system for an important endangered medicinal plant, Dracocephalum kotschyi, was developed through Agrobacterium rhizogenesmediated transformation by modifying the co-cultivation medium using five bacterial strains, A4, ATCC15834, LBA9402, MSU440, and A13 (MAFF-02-10266). A drastic increase in transformation frequency was observed when a Murashige and Skoog medium lacking NH 4 NO 3 KH 2 PO 4, KNO 3 and CaCl 2 was used, resulting in hairy root induction frequencies of 52.3 %, 69.6 %, 48.6 %, 89.0 %, and 80.0 % by A4, A13, LBA9402, MSU440, and ATCC15834 strains, respectively. For shoot induction, hairy roots and unorganized tumors induced by strain ATCC15834 were placed on an MS media supplemented with 0.1, 0.25, 0.5, and 1 mg/l BA plus 0.1 mg/l NAA. The high frequency of shoot regeneration and number of shoot were obtained in the medium containing 0.25 mg/l BA and 0.1 mg/l NAA. Root induction occurred from the base of regenerated shoots on the MS medium supplemented with 0.5 mg/l IBA after 10 days.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Sharafi

Sohi

Azadi

et al. 2014

Physiol Mol Biol Plants

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“…It is available as edible capsules and has been used to treat various cancers. According to the literature, this herbal medicine can reduce the viability of cancerous cell lines in mice (4).…”

Section: Introductionmentioning

confidence: 99%

“…Based on previous reports, alkaloids found in this plant can prevent tumor cell growth. This plant is an herbaceous perennial plant of the family Zygophyllaceae, native to different regions, including countries of the Middle East such as Iran (4,5). It can also improve cell lysis within 24 hours after use (6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Treatment Response and Side Effects of Spinal-Z in Patients with Metastatic Gastroesophageal Adenocarcinoma: A Double-Blind Randomized Controlled Trial

Mashak

Hoseinzadeh

Ehsanpour

et al. 2017

Jundishapur J Chronic Dis Care

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Background: Spinal-Z is a methanolic mixture of dried seed powder of Peganum harmala Linn. and leaf of Dracocephalum kotschyi Boiss. It is available as oral capsules and has been used to treat various cancers. The aim of this study was to evaluate the effects of Spinal-Z capsules (containing herbal extracts) on blood parameters and gastrointestinal symptoms of patients with metastatic gastric adenocarcinoma and to determine its potential side effects.

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“…Many indole alkaloids have been known for years and used in ancient cultures as psychotropic, stimulants and poisons. All these natural products derive from the amino acid tryptophan (1) 4 and show wide structural diversity, going from the simplest compound tryptamine (2), a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent, 5 to, for instance, harmine (3), a fluorescent harmala alkaloid which reversibly inhibits monoamine oxidase which shows also cytotoxicity against different cell lines, 6 and lysergic acid (4), a precursor of different ergoline alkaloids. Amide derivatives of 4 were used as psychedelic drugs.…”

Section: Introductionmentioning

confidence: 99%

Stereoselective Synthesis of 2-(2-Aminoalkyl)- and 1,3-Disubstituted Tetrahydro-1H-pyrido[4,3-b]- Benzofuran and Indole Derivatives

2016

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ABSTRACT. The addition of an allenyl indium intermediate to chiral N-tert-butanesulfinyl imines7 proceeds with high levels of diastereocontrol. The resulting homopropargylic amine derivatives 10 were transformed into 2-(2-aminoalkyl)benzofuran and indole derivatives 13 and 19, after Sonogashira-coupling with o-iodophenol or o-iodoaniline, followed by formation of the heteroaromatic ring through an intramolecular cyclization. Enantioenriched tetrahydropyridobenzofuran and indole derivatives 16 and 21 were prepared through a Picted-Spengler condensation of the free amines derived from compounds 15 and 20, involving the nucleophilic 3-position of the benzofuran or indole moiety.

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Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent

Cited by 138 publications

References 25 publications

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Evaluation of Treatment Response and Side Effects of Spinal-Z in Patients with Metastatic Gastroesophageal Adenocarcinoma: A Double-Blind Randomized Controlled Trial

Stereoselective Synthesis of 2-(2-Aminoalkyl)- and 1,3-Disubstituted Tetrahydro-1H-pyrido[4,3-b]- Benzofuran and Indole Derivatives

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