Xanthorrhizol attenuates dextran sulfate sodium-induced colitis via the modulation of the expression of inflammatory genes in mice

Cho, Jae-Young; Hwang, Jae Kwan; Chun, Hyang Sook

doi:10.1016/j.lfs.2011.03.007

Cited by 13 publications

(6 citation statements)

References 48 publications

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“…Several studies on transcriptome analysis have revealed that DSS induces proinflammatory cytokines and their receptors, matrix metalloproteinase family members, cell proliferation-related genes, and well-known mediators such as iNOS and COX-2 (Lee et al, 2009;Cho et al, 2011). The enhanced expression of iNOS and COX-2 by DSS in colon tissues was suppressed by up to 43.4 and 42.7%, respectively, by the administration of the L. plantarum strain CAU1055 (Figure 3B).…”

Section: Effects Of L Plantarum Cau1055 On Inflammatory Mediators In Dss-induced Colitis Modelmentioning

confidence: 96%

Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW264.7 cells and a dextran sulfate sodium–induced colitis animal model

Choi

Lee

Kim

et al. 2019

Journal of Dairy Science

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This study aimed to screen lactic acid bacteria (LAB) for their anti-inflammatory activity by using RAW264.7 cells and dextran sulfate sodium (DSS)-induced colitis. In all, 192 LAB strains were isolated from healthy human feces, of which 8 strains showed excellent nitric oxide (NO) inhibitory activity. Peptidoglycan extracts of these 8 LAB strains were subjected to NO assay, Western blot, and ELISA. Among the 8 tested strains, extracts of 4 strains significantly inhibited the production of NO, related enzyme activities such as inducible nitric oxide synthase and cyclooxygenase 2, and key cytokines such as tumor necrosis factor-α and IL-6 in RAW264.7 cells. The 4 strains belonged to Lactobacillus (CAU1054, CAU1055, CAU1064, and CAU1301). Oral administration of the 4 strains inhibited DSS-induced body weight loss, colon shortening, and colon damage in ICR mice. The colon tissue of the mice treated with Lactobacillus plantarum strain CAU1055 had significantly reduced levels of inducible nitric oxide synthase, cyclooxygenase 2, tumor necrosis factor-α, and IL-6. We found that strain CAU1055 could be used as a candidate probiotic strain for the prevention and treatment of inflammatory bowel disease. Further studies are warranted to confirm the mechanisms of interaction between peptidoglycan of L. plantarum strain CAU1055 and upstream cellular signaling mediators.

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Section: Effects Of L Plantarum Cau1055 On Inflammatory Mediators In Dss-induced Colitis Modelmentioning

confidence: 96%

Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW264.7 cells and a dextran sulfate sodium–induced colitis animal model

Choi

Lee

Kim

et al. 2019

Journal of Dairy Science

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“…Transcriptome analysis using cDNA microarray has shown that cytokines, chemokines, adhesion molecules, and acute-phase proteins such as S100a8, Saa3, and Hp play an important role in the regulation of inflammation [10] , [18] , [21] , [37] , [1] , [39] . In the present study, CA treatment suppressed the expression of DSS-induced inflammatory genes including acute-phase proteins such as S100a8 and Saa3, proinflammatory cytokines such as IL-1β and TNF-α, and adhesion molecules such as Mmp3 and Mmp10 ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, CA treatment suppressed the expression of DSS-induced inflammatory genes including acute-phase proteins such as S100a8 and Saa3, proinflammatory cytokines such as IL-1β and TNF-α, and adhesion molecules such as Mmp3 and Mmp10 ( Table 2 ). The acute-phase proteins are involved in triggering an immune reaction in the colon mucosa and in initiating an inflammatory response [10] , [25] . In particular, S100 calcium-binding proteins S100a6 and S100a8 have been shown to stimulate the adhesion and migration of neutrophils [27] .…”

Section: Discussionmentioning

confidence: 99%

“…Because of its ability to damage the epithelium and because the DSS-induced colitis animal model mimics the morphology and clinical symptoms of human UC, DSS is the chemical used most often to induce colitis [13] , [26] . cDNA microarray analysis has shown that DSS affected the expression of different sets of genes, in particular those involved in the acute inflammatory response, leukocyte activation, and cell adhesion, proliferation, and differentiation and these genes were regulated by the treatment of lactic acid bacteria and xanthorrhizol [10] , [18] . However, the profile of the genes regulated by CA treatment has not been investigated using transcriptome analysis in UC colon tissues.…”

Section: Introductionmentioning

confidence: 99%

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β-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation

Cho¹,

Kim

Kim³

et al. 2015

Toxicology Reports

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We examined the modulatory activity of β-caryophyllene (CA) and gene expression in colitic colon tissues in a dextran sulfate sodium (DSS)-induced colitis model. Experimental colitis was induced by exposing male BALB/c mice to 5% DSS in drinking water for 7 days. CA (30 or 300 mg/kg) was administered orally once a day together with DSS. CA administration attenuated the increases in the disease activity index, colon weight/length ratio, inflammation score, and myeloperoxidase activity in DSS-treated mice. Microarray analysis showed that CA administration regulated the expression in colon tissue of inflammation-related genes including those for cytokines and chemokines (Ccl2, Ccl7, Ccl11, Ifitm3, IL-1β, IL-28, Tnfrsf1b, Tnfrsf12a); acute-phase proteins (S100a8, Saa3, Hp); adhesion molecules (Cd14, Cd55, Cd68, Mmp3, Mmp10, Sema6b, Sema7a, Anax13); and signal regulatory proteins induced by DSS. CA significantly suppressed NF-κB activity, which mediates the expression of a different set of genes. These results suggest that CA attenuates DSS-induced colitis, possibly by modulating the expression of genes associated mainly with colon inflammation through inhibition of DSS-induced NF-κB activity.

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“…The valerenic acid is 0.3 to 3% of the essential oil valerian. The sesquiterpene xanthorrhizol is also present in the ginger rhizome, Turmeric xanthorrhiza, an Asian plant which is associated to numerous benefits including antioxidant properties [35]. Other sesquiterpene alcohols are also present in the essential oil of valerian, including valerenol.…”

Section: From Valerianmentioning

confidence: 99%

The Medical use of Lemon Balm (Melissa officinalis) and Valerian (Valeriana officinalis) as Natural Sedatives: Insight into their Interactions with GABA Transmission

Pineau¹,

Legros²,

Mattei³

2016

Int J Clin Pharmacol Pharmacother

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Lemon balm (Melissa officinalis) and valerian (Valeriana officinalis) have been consumed by humans since Antiquity, usually as herbal tea and brewing, for their sedative and relaxing capacities. These properties are associated with empirical observations of the effects of these plants on the body. But since the advent of phytotherapy as alternative medicine, it appeared on the market alcoholic extracts or essential oils, for which the same indications are claimed. It is therefore necessary to clarify or define the mechanisms of action of their various constituents to explain their effectiveness. We review here the current knowledge about the pharmacological properties -particularly the molecular targets -of the bioactive compounds of lemon balm and valerian. In this way, the activities of lemon balm and valerian, empirically observed throughout the body, can be explained and objectified at the molecular and cellular levels thanks to the mode of action of their molecular contents (terpenoids and phenolic derivatives). Our interest is to scientifically explain the pharmacological effects of these two plants in traditional medicine.

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Xanthorrhizol attenuates dextran sulfate sodium-induced colitis via the modulation of the expression of inflammatory genes in mice

Cited by 13 publications

References 48 publications

Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW264.7 cells and a dextran sulfate sodium–induced colitis animal model

Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW264.7 cells and a dextran sulfate sodium–induced colitis animal model

β-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation

The Medical use of Lemon Balm (Melissa officinalis) and Valerian (Valeriana officinalis) as Natural Sedatives: Insight into their Interactions with GABA Transmission

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