Xantogranuloma juvenil: una entidad con amplio espectro clínico

Martín, M.J. Hernández-San; Vargas‐Mora, Pablo; Araníbar, Ligia

doi:10.1016/j.ad.2020.07.004

Cited by 29 publications

(13 citation statements)

References 51 publications

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“…11 It is a benign disease and, in general, does not require treatment; however, if systemic involvement is present, treatment with corticosteroids and vinblastine may be indicated. 12 In case 2, the patient had associated neutropenia. Based on this, secondary causes were initially looked for, such as infections, mainly of the TORCH group, which manifest as hepatosplenomegaly, anemia, thrombocytopenia, and the blueberry muffin syndrome appearance with bluish subcutaneous nodules.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of non-malignant diseases mimicking leukemia cutis: A report of two cases

et al. 2023

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The infiltration of leukemia cells into the skin, known as leukemia cutis, is a rare presentation of this disease and accounts for a diagnostic challenge.The main differential diagnoses include infections, other neoplastic diseases with skin involvement and histiocytic disorders, among others, as they entail different prognostic and therapeutic approaches.Here we describe two patients who were initially diagnosed with leukemia cutis, whose final diagnosis was of non-malignant diseases.

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Section: Discussionmentioning

confidence: 99%

Clinical presentation of non-malignant diseases mimicking leukemia cutis: A report of two cases

et al. 2023

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“…11 Se trata de una patología benigna y, en general, no requiere tratamiento, sin embargo, si se presenta compromiso sistémico, se puede utilizar un esquema de corticoides y vinblastina. 12 En el caso 2 el paciente presentó neutropenia asociada. Esto motivó inicialmente la búsqueda de causas secundarias, como infecciones, principalmente del grupo TORCH, que se manifiestan con hepatoesplenomegalia, anemia, trombocitopenia y el aspecto blueberry muffin syndrome con nódulos subcutáneos azulados.…”

Section: Figura 3 Anatomía Patológica Del Caso Número 2 Se Puede Obse...unclassified

Presentación clínica de patologías no malignas que simulan leucemia cutis: a propósito de dos casos

2023

Arch Argent Pediat

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La infiltración cutánea por células leucémicas conocida como leucemia cutis es una presentación infrecuente de esta patología y constituye un desafío diagnóstico.Los diagnósticos como infecciones, otras patologías neoplásicas con afectación cutánea y los trastornos histiocíticos, entre otros, constituyen los principales diagnósticos diferenciales, ya que configuran un escenario pronóstico y terapéutico diferente.Se presentan dos pacientes que fueron diagnosticados inicialmente como leucemia cutis, cuyo diagnóstico final fue de patologías no malignas.

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“…Diagnosis is usually clinical, but diagnostic skin biopsy is recommended in case of multiple lesions to rule out other pathologic processes. Histology shows dense, well-demarcated dermal lymphohistiocytic infiltration interlaced with giant cells, and immunohistochemistry positive for macrophage markers (CD68, CD163, KiM1P, anti-FXIIIa, vimentin and anti-CD4) and negative for S100, CD1a and CD207, specific for Langerhans cells [2][3][4] . Differential diagnosis, mainly in multiple forms, includes: Langerhans cell histiocytosis, other non-Langerhans cell histiocytosis (cephalic histiocytosis, generalized eruptive histiocytoma, giant cell reticulohistiocytoma), urticaria pigmentosa, tuberous xanthomas, dermatofibroma, angiomas, nevus, molluscum contagiosum and pyogenic granuloma 5 .…”

Section: Main Textmentioning

confidence: 99%

“…Considering that extracutaneous involvement is rare, there is no consensus on the need for additional tests in patients with no associated systemic symptoms. Some authors advocate neuro-ophthalmologic evaluation and the performance of complementary tests, such as blood analysis with hemogram and liver profile and additional imaging tests, in high-risk cases: new diagnosis, multiple skin lesions, age younger than 2 years, or signs and symptoms suggestive of visceral involvement 2,3,6 .…”

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confidence: 99%