XantPhos Pd-G3 as an Efficient Catalyst: Microwave-Assisted C–S Cross-Coupling Reaction in DMF

Abstract

Buchwald precatalyst (XantPhos Pd-G3) was employed for the first time in a C-S cross-coupling reaction involving 2-(4-bromo phenyl) benzothiazole or 5-bromo-2,1,3-benzothiadiazole with various benzene thiols in DMF, K2CO3 as a base, under microwave irradiation at 80 oC, 200W. Good to excellent yields of the desired products were obtained under microwave conditions. Other significant benefits of this synthetic approach are low catalyst loading, short reaction times, and eco-friendly conditions. Additionally, we have successfully synthesized 29 compounds, some of which are new in this protocol.

Pd-G3 XantPhos Mediated Approach to Bis-arylsulfenyl-benzo-2,1,3-thiadiazoles under Microwave Irradiation in DMF: Synthesis and Fluorescent Properties

“…The synthesis of arylsulfenyl-benzo-2,1,3-thiadiazoles has received much attention. 14 15 In this context, we report a direct one-pot synthesis of arylsulfenyl-benzo-2,1,3-thiadiazoles, in the presence of a palladium catalyst, from various thiophenols and 4,7-dibromobenzo[ c ][1,2,5]thiadiazole in DMF, with K 2 CO 3 as a base, under microwave conditions at 75 °C, 200 W (100 psi). We also investigated the photophysical properties, including fluorescence and UV/Vis analyses of these compounds.…”