Xenon Does Not Impair the Responsiveness of Cardiac Muscle Bundles to Positive Inotropic and Chronotropic Stimulation

Schroth, Sylvia; Schotten, Ulrich; Alkanoglu, Orkide; Reyle-Hahn, M.; Hanrath, Peter; Rossaint, Rolf

doi:10.1097/00000542-200202000-00030

Cited by 34 publications

(18 citation statements)

References 8 publications

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“…Thus, confirmed is the data оn cardioprotective effect of xenon which consists in maintaining the cardiovascular stability [15]. At the same time absence of the xenon effect on general he modynamic parameters has been observed [16].…”

Section: Discussionsupporting

confidence: 53%

“…Detected is improvement of psychological state. Thus, the positive effect of xenon in oncology patients in early postoper ative period involved neurohumoral stabilization and functional state optimization of the patients' state [15,18]. The ability to prevent disorders associated with the postcastration syndrome will allow the patients to maintain their functional and social status, which is a prerequisite for a full life [19].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies

Rudenko¹,

Arapova²,

Protasova³

et al. 2017

Cardiometry

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies

Rudenko¹,

Arapova²,

Protasova³

et al. 2017

Cardiometry

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“…by echocardiography). It is, however, known that xenon does not share the inhibitory effects of volatile anaesthetics on myocardial calcium channels and contractility of isolated muscle bundles (Hü neke et al 2001, Schroth et al 2002. Further it has not been shown to have any influence on left ventricular performance in dogs (Hettrick et al 1998) or on fractional area change in transoesophageal echocardiography in humans (Luttropp et al 1993).…”

Section: Hormonesmentioning

confidence: 99%

The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs

et al. 2008

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SummaryThe noble gas xenon seems to have minimal cardiovascular side-effects and so may be an ideal anaesthetic agent when investigating cardiovascular physiology. In comparison with standard modern anaesthetics, we investigated the haemodynamic and hormonal effects of xenon in Beagle dogs. After a 30 min baseline period, anaesthesia was induced with propofol and maintained with either (1) 1.2% isoflurane/70% nitrous oxide (N 2 O), (2) 0.8% isoflurane/ 0.5 mg/kg/min remifentanil or (3) 63% xenon/0.5 mg/kg/min remifentanil (n ¼ 6 per group).Haemodynamics were recorded and blood samples taken before and 60 min after induction. Mean arterial blood pressure (MAP) was higher in conscious dogs than during isoflurane/N 2 O (86 + 2 vs. 65 + 2 mmHg, mean + SEM) and isoflurane/remifentanil anaesthesia (95 + 2 vs. 67 + 3 mmHg), whereas MAP did not decrease significantly in response to xenon/ remifentanil anaesthesia (96 + 4 vs. 85 + 6 mmHg). Bradycardia was present during isoflurane/remifentanil (54 + 2/min) and xenon/remifentanil (40 + 3/min), but not during isoflurane/N 2 O anaesthesia (98 + 3/min, P , 0.05). Xenon/remifentanil anaesthesia induced the highest reduction in cardiac output (CO) ( -61%), and the highest increase in systemic vascular resistance (þ120%) among all treatment groups (P , 0.05). A simultaneous increase in endogenous adrenaline and noradrenaline concentrations could only be observed in the xenon/remifentanil group, whereas angiotensin II and vasopressin concentrations increased in all groups. In conclusion, xenon/remifentanil anaesthesia maintains MAP but reduces heart rate and CO and is associated with a considerable stimulation of vasopressor hormones in Beagle dogs. Therefore, xenon/remifentanil exerts a new quality of adverse haemodynamic effects different from volatile anaesthetics and may not perform better during studies of cardiovascular physiology.

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“…Clinically and experimentally, xenon has shown favourable effects with respect to haemodynamic stability and cardiac function in a variety of species, including humans, in both in vivo and in vitro studies [3][4][5][20][21][22][23][24][25]. However, the impact of these findings on morbidity and mortality in high risk surgical patients is unknown.…”

Section: Discussionmentioning

confidence: 99%

Comparison of xenon‐based anaesthesia compared with total intravenous anaesthesia in high risk surgical patients*

et al. 2005

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SummaryXenon, a noble gas with anaesthetic and analgesic properties, has gained renewed interest due to its favourable physical properties which allow a rapid emergence from anaesthesia. However, high costs limit its use to a subset of patients who may benefit from xenon, thereby offsetting its costs. To date, there are only limited data available on the performance of xenon in high risk patients. We studied 39 patients with ASA physical status III undergoing aortic surgery. The patients were randomly assigned to either a xenon (Xe, n = 20) or a TIVA (T, n = 19) group. Global cardiac performance and myocardial contractility were assessed using transoesophageal echocardiography, and myocardial cell damage with troponin T and CK-MB. Echocardiographic measurements were made prior to xenon administration, following xenon administration, and after clamping of the abdominal aorta, after declamping and at corresponding time points in the TIVA group. Laboratory values were determined repeatedly for up to 72 h. Data were analysed using two-way ANOVA factoring for time and anaesthetic agent or with ANCOVA comparing linear regression lines. No significant differences were found in global myocardial performance, myocardial contractility or laboratory values at any time during the study period. Mean (SEM) duration of stay on the ICU (xenon: 38 ± 46 vs. TIVA 25 ± 15 h) or in hospital (xenon: 14 ± 12 vs. TIVA 10 ± 6 days) did not differ significantly between the groups. Although xenon has previously been shown to exert superior haemodynamic stability, we were unable to demonstrate an advantage of xenon-based anaesthesia compared to TIVA in high risk surgical patients.

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Xenon Does Not Impair the Responsiveness of Cardiac Muscle Bundles to Positive Inotropic and Chronotropic Stimulation

Abstract: Xenon does not alter myocardial contractility and the response to inotropic stimuli such as calcium, isoproterenol, or increase in pacing frequency in isolated guinea pig ventricular muscle bundles.

Cited by 34 publications

References 8 publications

Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies

Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies

The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs

Comparison of xenon‐based anaesthesia compared with total intravenous anaesthesia in high risk surgical patients*

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Xenon Does Not Impair the Responsiveness of Cardiac Muscle Bundles to Positive Inotropic and Chronotropic Stimulation

Abstract: Xenon does not alter myocardial contractility and the response to inotropic stimuli such as calcium, isoproterenol, or increase in pacing frequency in isolated guinea pig ventricular muscle bundles.

Cited by 34 publications

References 8 publications

Xenon effect on electro­physiological markers in oncology patients with postcastration ­syndrome during early post­operative period: pilot studies

Xenon effect on electro­physiological markers in oncology patients with postcastration ­syndrome during early post­operative period: pilot studies

The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs

Comparison of xenon‐based anaesthesia compared with total intravenous anaesthesia in high risk surgical patients*

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Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies

Xenon effect on electrophysiological markers in oncology patients with postcastration syndrome during early postoperative period: pilot studies