XPD Lys751Gln Polymorphisms and the Risk of Esophageal Cancer: An Updated Meta-Analysis

Guo, Xufeng; Wang, Jun; Lei, Xiaofei; Zeng, Yanping; Dong, Weiguo

doi:10.2169/internalmedicine.54.3256

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…Xue et al (2012) conducted a meta-analysis with 12 case-controls studies and found that the ERCC2 rs13181 polymorphism is correlated with an increased risk of gastric cancer. Guo et al (2015) conducted a meta-analysis with 21 case-control studies and reported that theERCC2 rs13181 polymorphism contributes to susceptibility to esophageal cancer. Li et al (2014) performed a meta-analysis and reported that the ERCC2 rs13181 polymorphism is associated with susceptibility to lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The rs13181 polymorphism of ERCC2 is a T to G substitution at the 751 locus, which may alter the enzymatic activity of the encoded protein. ERCC2 rs13181 is associated with various cancers, such as gastric cancer, esophageal cancer, non-small cell lung cancer, hepatocellular carcinoma, prostate cancer, skin cancer, and bladder cancer (Yin et al, 2013;Zhu et al, 2013;Li et al, 2014;Ramaniuk et al, 2014;Zhu et al, 2014;Yang et al, 2015;Guo et al, 2015). Previous studies have reported the association between the ERCC2 rs13181 polymorphism and glioma development, but the results are inconclusive (Caggana et al, 2001;Wrensch et al, 2005;Yang et al, 2005;Liu et al, 2009;Luo et al, 2013;Rodriguez-Hernandez et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

Gao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People's Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism was analyzed using a polymerase chain reaction -restriction fragment length polymorphism assay. By conditional regression analysis, we found that the GG genotype of the ERCC2 rs13181 polymorphism is associated with susceptibility to gliomas when compared to the TT genotype (OR = 2.05, 95%CI = 1.11-3.79). In the recessive model, the GG genotype is associated with an increased risk of gliomas when compared with the TT+TG genotype (OR = 1.87, 95%CI = 1.03-3.37). In conclusion, the ERCC2 rs13181 polymorphism is correlated with an increased risk of gliomas in codominant and recessive models, which suggests that this polymorphism could influence the etiology of gliomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

Gao

et al. 2016

Genet. Mol. Res.

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“…To date, molecular epidemiological studies on two GSNPs in this gene, namely, rs369191500 polymorphism (codon 312, Asp to Asn) and rs13181 polymorphism (codon 751, Lys to Gln), have been conducted by diferent laboratories [54]. Genotype-phenotype analyses have shown that these two GSNPs are associated with low DNA repair ability, which might modify DNA-adduct levels, p53 gene mutation, and risk of cancer [55,56]. For genetic polymorphisms among Guangxiese population, a total of four epidemiological studies have been conducted via case-control design ( [58].…”

Section: Xeroderma Pigmentosum D (Xpd) Gsnps and Afb1-hcc Among Guangmentioning

confidence: 99%

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Wu¹,

Xi²,

Lü³

et al. 2017

Genetic Polymorphisms

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Alatoxin B1 (AFB1) is an important environmental carcinogen for the development of hepatocellular carcinoma (HCC). HCC is a complex disease likely resulting from genetic single nucleotide polymorphisms (GSNPs) of multiple interacting genes and geneenvironment interactions. Recent eforts have been made to analyze the associations between risk of this malignancy and GSNPs in genes involved in the repair of DNA damage induced by AFB1. Here, we reviewed the results of published case-control studies that have examined the efects of common alleles of all susceptible DNA repair genes, including XRCC1, XRCC3, XRCC4, XRCC7, XPC, and XPD, on risk of AFB1-related HCC among Guangxi population. Statistically signiicant diferences in genotype frequencies found in case-control comparisons were rs25487, rs80309960, rs861539, rs7003908, rs28383151, rs3734091, rs13181, and rs2228001 polymorphism. The overall efects of these GNSPs were moderate in terms of relative risk, with ORs ranging from 2 to 10. Furthermore, some evidence of the interaction of GSNPs in DNA repair genes and AFB1 exposure modulate risk of this cancer was also found, although the results require conirmation with larger sample size studies.

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“…For 51 SNPs identified by meta‐analysis, 38 SNPs had statistically significant association with EC or ESCC susceptibility . Meta‐analysis results showed that there were 27 SNPs associated with increased EC or ESCC risk, whereas 11 SNPs decreased the risk of EC or ESCC risk.…”

Section: Resultsmentioning

confidence: 94%

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studies

Tian

Liu

et al. 2019

Cancer Medicine

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An increasing number of publications had reported the association between single‐nucleotide polymorphisms (SNPs) and esophageal cancer (EC) risk in the past decades. Results from these publications were controversial. We used PubMed, Medline, and Web of Science to identify meta‐analysis articles published before 30 July 2018, that summarize a comprehensive investigation for cumulative evidence of genetic polymorphisms of EC and its subtype risk. Two methods, Venice criteria and false‐positive report probability (FPRP) tests, were used to assess cumulative evidence of significant associations. At last, 107 meta‐analyses were considered to be in conformity with the inclusion criteria, yielding 51 variants associated with EC or esophageal squamous cell carcinoma (ESCC). Thirty‐eight variants were considered to be nominally significant associated with risk of EC or ESCC, whereas the rest showed non‐association. In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak. Additionally, 17 SNPs were verified noteworthy in six genomewide association studies (GWAS) using FPRP methods. Collectively, this review offered a comprehensively referenced information with cumulative evidence of associations between genetic polymorphisms and EC and ESCC risk.

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XPD Lys751Gln Polymorphisms and the Risk of Esophageal Cancer: An Updated Meta-Analysis

Cited by 8 publications

References 33 publications

ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta‐analysis and genome‐wide association studies

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