XRCC1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Moghaddam, Ali Sanjari; Nazarzadeh, Milad; Moghaddam, Hossein Sanjari; Bidel, Zeinab; Keramatinia, Aliasghar; Darvish, Hossein; Mosavi‐Jarrahi, Alireza

doi:10.7314/apjcp.2016.17.s3.323

Cited by 11 publications

(4 citation statements)

References 36 publications

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“…In agreement with our results, a study in Indian populations showed that XRCC1 rs25487 polymorphism was 6‐fold higher in pre‐menopausal BC patients 20 . A study in Caucasian Portuguese population and a recently published meta‐analysis suggested that Gln/Gln genotype increased risk of BC in post‐menopause women aged over 55 years 43,44 . In addition, XPG rs17655 and hMSH2 rs4987188 polymorphisms were found to be associated with histopathological characteristics of breast tumors.…”

Section: Discussionsupporting

confidence: 91%

The interplay between XPG‐Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis

et al. 2022

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Background Reproductive history and genetics are well‐known risk factors of breast cancer (BC). Little is known about how these factors interact to effect BC. This study investigated the association of ten polymorphisms in DNA repair genes with BC susceptibility in the Tanzanian samples and further analyzed the association between reproductive risk factors and disease risk Methods A hospital‐based case–control study in 263 histopathological confirmed BC patients and 250 age‐matched cancer‐free controls was carried out. Allelic, genotypic, and haplotype association analyses were executed. Also, multifactor dimensionality reduction (MDR), and interaction dendrogram approaches were performed. Results The frequency of genotypic and allelic variants of XRCC1 ‐Arg399Gln (rs25487), XRCC2 ‐Arg188His (rs3218536), XRCC3 ‐Thr241Met (rs861539), XPG ‐Asp1104His (rs17655), and MSH2 ‐Gly322Asp (rs4987188) were significantly different between the groups ( p < 0.05). Moreover, XRCC1 ‐Arg399Gln (rs25487), XRCC3 ‐Thr241Met (rs861539), and XPG ‐Asp1104His (rs17655) were associated with the increased risk of BC in co‐dominant, dominant, recessive, and additive genetic‐inheritance models ( p < 0.05). XRCC1 ‐Arg/Gln genotype indicated a 3.1‐fold increased risk of BC in pre‐menopausal patients ( p = 0.001) while XPG ‐His/His genotype showed a 1.2‐fold increased risk in younger BC patients (<40 years) ( p = 0.028). Asp/His+His/His genotypes indicated a 1.3‐fold increased risk of BC in PR+ patients and a 1.1‐fold decreased risk of BC in luminal‐A patients ( p = 0.014, p = 0.020, respectively). MDR analysis revealed a positive interaction between BC and the XPG ‐Asp1104His (rs17655) together with family history of cancer in the first‐degree relatives. Dendrogram analysis indicated that the XPG ‐Asp1104His (rs17655) and family history of cancer in first‐degree relatives were significantly synergistic and might be associated with an elevated risk of BC in Tanzania. Conclusions The XPG ‐Asp1104His (rs17655) might exert both independent and interactive effects on BC development in the Tanzanian women.

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Section: Discussionsupporting

confidence: 91%

The interplay between XPG‐Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis

et al. 2022

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“…In this scenario, we hypothesized that polymorphisms in XPC gene, being important in the sensitivity against the development of different types of cancer (Bahceci et al, 2015), may reflect a reduced life-expectancy in carrier subjects and may explain the significant low frequency of XPC exon 15 C-allele observed in the present study among subjects belonging to oldest age group. Conversely, there is no consensus regarding the possible association between XRCC1 Arg194Trp and XRCC1 Arg280His with different types of cancer (Moghaddam et al, 2016;Dylawerska et al, 2017), data that may explain the lack of association of these gene polymorphisms with longevity, as observed in our study.…”

Section: Discussioncontrasting

confidence: 82%

Association of Metabolic and DNA-repair gene polymorphisms with Longevity: a role forGSTT1, GSTPandXPCgenes

Scarfò

Sciandra

Santovito

2020

Preprint

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Aging and longevity are complex processes controlled at different levels, including genetic level. We evaluated the association of seven drug and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 exon 7 A>G, GSTT1 null, GSTM1 null, GSTP A>G, XRCC1 exon 6 C>T, XRCC1 exon 9 A> G and XPC exon 15 A>C gene polymorphisms. The association between the analyzed gene polymorphisms and longevity was evaluated by dividing the sample into three age groups: 10-50, 51-85, and 86-98.We observed a significant decrease in the frequency of the GSTT1 null, GSTP G and XPC C alleles in the oldest group with respect to the youngest one and with respect to 51-85 age group. We obtained the same results also subdividing the sample into 1-85 and 86-98 age groups. The general linear model analyses confirmed a significant decreasing trend of the above mentioned alleles with age. We hypothesized that these minor alleles, being important in the sensitivity against the development of different types of cancer, may reflect a reduced life-expectancy in carrier subjects and may explain their significantly lower frequency observed among subjects belonging to oldest age group.

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“…Beatriz Regina Lima de Aguiar, Eliete Neves Silva Guerra and Paula Elaine Diniz dos Reis* University of Brasília, Brasília, Brazil *Address all correspondence to: pauladiniz@unb.br XRCC1 plays an important role in DNA repair following base excision damage [66]. Nanda et al [67] and Raturi et al [68] found that polymorphic variants in XRCC1 for the SNP encoded by rs1799782 increased the risk of developing severe ARD.…”

Section: Author Detailsmentioning

confidence: 99%

Radiogenomics: A Personalized Strategy for Predicting Radiation-Induced Dermatitis

Aguiar¹,

Guerra²,

Reis³

2023

Radiation Therapy

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Although radiation therapy (RT) planning and execution techniques have evolved to minimize radiotoxicity to a considerable extent, adjacent tissues still receive a substantial dose of ionizing radiation, resulting in radiotoxicities that may limit patients’ quality of life. Depending on the location of tissue injury and the severity of the cellular response, there may also be a need to interrupt RT, thus interfering with the prognosis of the disease. There is a hypothesis that genetic factors may be associated with individual radiosensitivity. Recent studies have shown that genetic susceptibility accounts for approximately 80% of the differences in toxicity. The evolution of genomic sequencing techniques has enabled the study of radiogenomics, which is emerging as a fertile field to evaluate the role of genetic biomarkers. Radiogenomics focuses on the analysis of genetic variations and radiation responses, including tumor responses to RT and susceptibility to toxicity in adjacent tissues. Several studies involving polymorphisms have been conducted to assess the ability to predict RT-related acute and chronic skin toxicities, particularly in patients with breast and head and neck cancers. The purpose of this chapter is to discuss how radiogenomics can help in the management of radiotoxicities, particularly radiodermatitis.

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XRCC1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Cited by 11 publications

References 36 publications

The interplay between XPG‐Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis

The interplay between XPG‐Asp1104His polymorphism and reproductive risk factors elevates risk of breast cancer in Tanzanian women: A multiple interaction analysis

Association of Metabolic and DNA-repair gene polymorphisms with Longevity: a role forGSTT1, GSTPandXPCgenes

Radiogenomics: A Personalized Strategy for Predicting Radiation-Induced Dermatitis

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