Xylan, a Promising Hemicellulose for Pharmaceutical Use

Silva, Acarilia Eduardo da; Marcelino, Henrique Rodrigues; Gomes, Monique Christine Salgado; Oliveira, Elquio Eleamen; Nagashima, Toshiyuki; Egito, Eryvaldo Sócrates Tabosa do

doi:10.5772/33070

Cited by 22 publications

(23 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Utilization of xylan, which is found in cereal grains, has been repeatedly established in Prevotella species and in P. copri specifically (Accetto and Avgustin, 2019;da Silva et al, 2012;Dodd et al, 2011;Tan et al, 2018). Two distinct PULs encoding enzymes not previously associated with xylan catabolism were identified for corn xylan, birchwood xylan, and arabinoxylan in multiple B. ovatus and B. xylanisolvens strains (Rogowski et al, 2015).…”

Section: Prevotella Polysaccharide Utilizationmentioning

confidence: 93%

Distinct polysaccharide growth profiles of human intestinalPrevotella copriisolates

Fehlner-Peach

Magnabosco

Raghavan

et al. 2019

Preprint

View full text Add to dashboard Cite

The gut-dwelling Prevotella copri, the most prevalent Prevotella species in human gut, have been associated with diet as well as disease, but our understanding of their diversity and functional roles remains rudimentary, as studies have been limited to 16S and metagenomic surveys and experiments using a single type strain. Here, we describe the genomic diversity of 83 P. copri isolates from 11 donors. We demonstrate that genomically distinct isolates, which can be categorized into different P. copri complex clades, utilize defined sets of plant polysaccharides that can be predicted in part from their genomes and from metagenomic data.This study thus reveals both genomic and functional differences in polysaccharide utilization between several novel human intestinal P. copri strains.

show abstract

Section: Prevotella Polysaccharide Utilizationmentioning

confidence: 93%

Distinct polysaccharide growth profiles of human intestinalPrevotella copriisolates

Fehlner-Peach

Magnabosco

Raghavan

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, knowledge of the kinetics of hemicellulose removal and delignification of cellulosic biomass, specifically oat hulls in this work, would be helpful in the selection of process parameters to provide a cellulosic material with a specific composition for a specific application. The objectives of this work are: (1) to investigate the behavior of (acidic) hemicellulose removal under process parameters and to optimize the parameters for full removal of hemicellulose; and (2) to investigate the influence of biomass prehydrolysis (for full removal of hemicellulose) on delignification efficiency and to compare the results with delignification of untreated biomass in achieving higher cellulose content in the coproduct.…”

Section: Introductionmentioning

confidence: 99%

“…Hemicelluose is a plentiful polysaccharide in nature which is ranked the second after cellulose in terms of abundance. 1 Because of its heterogeneous composition, it is sometimes termed hemicelluloses, which is a group of polysaccharides. 2 There has been increasing interest in xylan, the main polymer in hemicellulose with the backbone of b-(1-4)-linked-Dxylopyranosyl units (shown in Figure 1), because of its wide ranging potential application in the pharmaceutical, food, and cosmetic industries.…”

Section: Introductionmentioning

confidence: 99%

Delignification of intact biomass and cellulosic coproduct of acid‐catalyzed hydrolysis

2015

View full text Add to dashboard Cite

The kinetics of acid-catalyzed hemicellulose removal and also alkaline delignification of oat hull biomass were investigated. All three operational parameters namely, catalyst concentration (0.10-0.55 N H 2 SO 4 ), temperature (110-130 C), and residence time (up to 150 min) affected the efficiency of hemicellulose removal, with 100% of hemicellulose removed by appropriate selection of process parameters. Analysis of delignification kinetics (in the temperature range of 30-100 C) indicated that it can be expressed very well by a two-phase model for the crude biomass and also for the hemicellulose-prehydrolyzed material. The application of acid-catalyzed prehydrolysis improved the capacity of lignin dissolution especially at lower temperatures (30 and 65 C) and accelerated the dissolution of lignin. This acceleration of delignification by prehydrolysis was possible at all levels of temperature in the bulk phase; however, results were more significant at the lower temperatures in the terminal phase.

show abstract

“…Indeed, these results were expected because this material is considered highly stable, nontoxic, and hydrophilic [10,32], even though anti-proliferative activity of xylan against HeLa cells has been reported as its AC50 = 1 mg/mL, as well as the activity of other polysaccharides [13]. Despite its low toxicity, at 24.8 mg·mL −1 the cell viability decreased (Figure 7a,c), probably as a result of the saturation of the medium with xylan and, consequently, the precipitation of xylan as result of its low solubility in aqueous medium at physiological pH [33].…”

Section: Cell Viability Through Mtt Assaymentioning

confidence: 92%

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

et al. 2015

View full text Add to dashboard Cite

Interfacial cross-linking (ICL) has been considered a feasible technique to produce polysaccharide-based microparticles (PbMs), even though only a few studies have been concerned with their biocompatibility. In this work, PbMs were prepared by the ICL method and characterized in regard to their in vitro biocompatibility, chemical linkages, and physical and thermal properties. First, the cell viability assay revealed that PbMs toxicity was concentration-dependent. Then, it was observed that the toxicity may be related to the way in which the binding occurred, and not exclusively to the stoichiometry between the polymer and the cross-linking agent. Moreover, the PbMs biosafety was predicted by the use of physicochemical procedures, which were able to identify unbound cross-linking agent residues and also to reveal the improvement of their thermal stability. Accordingly, this work suggests a step-by-step physicochemical procedure able to predict potential toxicity from micro-structured devices produced by polysaccharides. Likewise, the use of PbMs as a drug carrier should be cautiously considered.

show abstract

Xylan, a Promising Hemicellulose for Pharmaceutical Use

Cited by 22 publications

References 69 publications

Distinct polysaccharide growth profiles of human intestinalPrevotella copriisolates

Distinct polysaccharide growth profiles of human intestinalPrevotella copriisolates

Delignification of intact biomass and cellulosic coproduct of acid‐catalyzed hydrolysis

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

Contact Info

Product

Resources

About