Xylan-Based Hydrogels as a Potential Carrier for Drug Delivery: Effect of Pore-Forming Agents

Abstract

Pore-forming agents have a significant influence on the pore structure of hydrogels. In this study, a porogenic technique was employed to investigate the preparation of macroporous hydrogels which were synthesized by radical copolymerization of carboxymethyl xylan with acrylamide and N-isopropylacrylamide under the function of a cross-linking agent. Six kinds of pore-forming agents were used: polyvinylpyrrolidone K30, polyethylene glycol 2000, carbamide, NaCl, CaCO3, and NaHCO3. The application of these hydrogels is also discussed. The results show that pore-forming agents had an important impact on the pore structure of the hydrogels and consequently affected properties of the hydrogels such as swelling ratio and mechanical strength, while little effect was noted on the thermal property of the hydrogels. 5-Fluorouracil was used as a model drug to study the drug release of the as-prepared hydrogels, and it was found that the drug release was substantially improved after using the NaHCO3 pore-forming agent: a cumulative release rate of up to 71.05% was achieved.

Fungicide‐loaded and biodegradable xylan‐based nanocarriers

“…To date, most investigations used xylan hydrogels to load drugs and very few studies dealt with the encapsulation of pharmaceuticals. [7][8][9][10][11][12] Aside from applications in medicine, xylan is ideal as a carrier agent in agrochemical formulations due to its plant origin. However, to the best of our knowledge, no studies have reported the formation of pesticide-loaded xylan nanocarriers yet.…”

A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis

“…The swelling behavior of the hydrogel is a dynamic process, which depends on structural factors such as geometry, chemical composition of the polymeric network, the presence of pores and polymer–solvent interactions [60,61,62,63]. As AmB release from the hydrogel requires the previous solvation of the polymeric chains, swelling kinetic experiments were performed to better understand the mechanisms involved in this process.…”

Comparative analysis of alkaline-extracted hemicelluloses from Beech, African rose and Agba woods using FTIR and HPLC

“…In hardwoods, they occur mainly as O-acetyl-4-O-methylglucuronoxylan and in softwood they occur as arabino-4-O-methylglucuronoxylan ( Wang et al., 2020 ). Recently, tailored research on the use of hemicelluloses in the production of composites with more desirable properties are ongoing ( Chang et al., 2018 ).…”

“…These woods generate a large amount of wastes every year as sawdust. These by-products are potentially valuable materials that can be used for various biotechnological processes such as biofuel, enzyme, xylooligosaccharides production and in the construction of biomaterials ( Chakdar et al., 2016 ; Chang et al., 2018 ; Chinga-Carrasco, 2018 ).…”