Xylan from Pineapple Stem Waste: a Potential Biopolymer for Colonic Targeting of Anti-inflammatory Agent Mesalamine

Anindya, Atsarina Larasati; Oktaviani, Risa Dwi; Praevina, Benita Rachel; Damayanti, Sophi; Kurniati, Neng Fisheri; Riani, Catur; Rachmawati, Heni

doi:10.1208/s12249-018-1205-y

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Walz et al [40] studied the enzymatic degradability of acetylated inulin, which was prepared as a potential encapsulation material to achieve a colonic targeted delivery of mesalamine. Anindya et al [41] synthesized xylan-mesalamine conjugate as a promising colon triggered delivery system. Xylan was isolated from pineapple stem waste.…”

Section: Microbial/enzyme Sensitive Approachmentioning

confidence: 99%

Recent advances in mesalamine colonic delivery systems

Bayan

2020

Futur J Pharm Sci

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Background: Increased attention has been focused on the continuous development and improvement of mesalamine colonic specific delivery systems, for the effective treatment of inflammatory bowel diseases; thus enhancing therapeutic efficacy and reducing potential side effects. Mesalamine is a class IV drug, according to the Biopharmaceutics Classification System, used usually to treat inflammation associated with colon related diseases such as Crohn's disease and ulcerative colitis. Main text An ideal colon targeting system aims to deliver a therapeutic agent, selectively and effectively, to the colon. This system should ideally retain the drug release in the upper GI tract (stomach and small intestine); while trigger the drug release in the colon. Several approaches have been used to fabricate formulations to achieve a colon specific delivery of mesalamine such as; time dependent, pH responsive, enzymatic/microbial responsive and ultrasound mediated approaches. This overview outlines the recent advances in mesalamine-colon delivery approaches for the potential treatment of ulcerative colitis and Crohn' disease. Conclusion: A combined pH-time dependent delivery system can improve mesalamine colonic drug delivery via employing carriers capable of retarding mesalamine release in the stomach and delivering it at predetermined time points after entering the intestine. The existence of specific enzymes, produced by various anaerobic bacteria present in the colon advocates the advantage of designing enzyme sensitive systems and combining it with pHtime dependent system to improve mesalamine colonic delivery. The use of ultrasound has shown promises to effectively treat inflammatory bowel diseases.

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Section: Microbial/enzyme Sensitive Approachmentioning

confidence: 99%

Recent advances in mesalamine colonic delivery systems

Bayan

2020

Futur J Pharm Sci

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“…MIA is a metabolic inhibitor that breaks down the cellular aerobic glycolysis pathway. Intra-articular injection of MIA disrupts the glycolysis in chondrocytes by inhibiting glyceraldehyde-3-phosphatase dehydrogenase, which leads to chondrocytes death, neovascularization, necrosis and destruction of the subchondral bones, as well as inflammation (Bozimowski 2015;Steinmeyer et al 2018;Anindya et al 2019). Besides joint damage, MIA injection induces mechanical sensitivity of the ipsilateral hind paw and weight bearing deficit.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays it is important to optimize the pain sensitivity testing methods in animals in order to study OA and effectively develop therapeutic strategies. The histological analysis used to describe the models is a laborious and long-time stage, resulting in the determination of the morphological state of the tissues, rather than the physiological reactions of the body (Anindya et al 2019). Pain sensitivity tests on animals make it possible to assess the nature of the inflammation development and its suppression by the most obvious and complex parameters, which result from inflammation processes at the molecular, cellular and tissue levels.…”

Section: Introductionmentioning

confidence: 99%

A novel view of the problem of Osteoarthritis in experimental rat model

Паликов¹,

Palikova²,

Borozdina³

et al. 2020

RRP

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Introduction: The article presents the results of the functional tests to improve the assessment of MIA-induced osteoarthritis development and the effectiveness of NSAID therapy. Materials and methods: In the study, 26 male SD rats were used. MIA-induced osteoarthritis was simulated in the right knee joint. After an intra-articular injection of MIA, the animals were treated with ibuprofen and meloxicam. Pain assessment was studied in the following functional tests: incapacitance (hind limb weight bearing) test, von Frey test (mechanical allodynia), grip strength test, and knee diameter measurement. At the end of the study, a histological analysis of the knee joint was performed. Results and discussion: An intra-articular MIA injection reduced 1.5 times the paw withdrawal threshold. In the rats that suffered MIA-induced osteoarthritis, the difference between the diameters of the intact and injected joints was 1.05 mm, compared to 0.03 mm difference in the control group. Hind limb weight bearing asymmetry was 89.5% when simulating MIA-induced osteoarthritis. The muscular hind limb grip strength in rats with MIA-induced osteoarthritis was significantly reduced on 3rd and 7th days after simulating osteoarthritis. Ibuprofen and meloxicam showed significant efficacy in all the above tests, although ibuprofen effectiveness was more pronounced than that of meloxicam. Conclusion: The following functional tests were identified as the most significant and sufficient to assess the development of MIA-induced osteoarthritis and analgesic efficacy of NSAIDs: incapacitance test, allodynia test (von Frey filaments), measurement of hind limb grip strength and measurement of the diameter of the inflamed knee joint. The histological analysis made it possible to confirm the correspondence of the physiological response and pathological changes in the knee joint.

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