Xylanase supplementation to a wheat-based diet alleviated the intestinal mucosal barrier impairment of broiler chickens challenged byClostridium perfringens

Effects of Xylanase Supplementation and Citric Acid on Performance, Ileal Nutrients Digestibility, and Gene Expression of Intestinal Nutrient Transporters in Broilers Challenged with <i>Clostridium perfringens</i>

“…Probiotics can indirectly suppress the proliferation of pathogenic bacteria, such as C. perfringens (Annett et al, 2002). In addition, xylanase had positive effects on morphometric indices and increased the villus height-to-crypt depth ratio in different segments of the small intestine (Liu et al, 2012), resulting in a larger surface area available for digestion and absorption of nutrients. All these factors facilitated the digestibility of nutrients and improved the digestibility of protein for challenged broilers.…”

“…An increase in disaccharidase activity is associated with an increase in the capacity for disaccharide digestion and absorption in the epithelium (Moreno et al, 1995). Liu et al (2012) found that xylanase supplementation improves sucrose digestion in challenged broilers by reducing the number of pathogenic bacteria in the small intestine. In contrast, xylanase decreases the chyme viscosity that may prevent contact between bush border enzymes and their substrates by thickening the unstirred mucosal layer (Wang et al, 2005).…”

“…The NE challenge was a modified version of the method described by Liu et al (2012). A broiler C. perfringens type A field strain was isolated from a clinical case of NE at the Iranian Veterinary Culture Center (Mashhad, Iran).…”

“…The positive effects of xylanase may reduce intestinal functional disorders caused by C. perfringens infection. Liu et al (2012) noted that the xylanase enzyme reduced the impairment of the intestinal mucosal barrier in birds infected by C. perfringens. However, the possible mechanism(s) underlying the influence of xylanase on the nutrient digestibility in subclinical NE of starter broilers fed a wheat-based diet is largely unknown.…”

Effects of dietary essential oil and enzyme supplementation on growth performance and gut health of broilers challenged by Clostridium perfringens

“…C. perfringens challenge C. perfringens challenge was based on the model originally developed by Dahiya et al (2005) and modified by Liu et al (2012). C. perfringens type A strain isolated from a clinical case of NE was obtained from China Veterinary Culture Collection Center (Beijing, China).…”