YC-1, a potent antithrombotic agent, induces lipolysis through the PKA pathway in rat visceral fat cells

Chin, Chih Hui; Tsai, Feng-Chou; Chen, Sy Ping; Wang, Ke Chuan; Chang, Chao; Pai, Man Hui; Fong, Tsorng Harn

doi:10.1016/j.ejphar.2012.05.013

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…YC-1 can also modulate lipolysis, but in a cell-type-specific manner. In RAW 264.7 macrophage cells, YC-1 increased lipid droplet and oxidized LDL foam cell formation through cGMP-dependent protein kinase 129 , whereas in adipocytes, YC-1 induced lipolysis 130 . Another study revealed that YC-1 is a non-competitive inhibitor of p-glycoprotein (multidrug resistance protein 1 (MDR1; also known as ABCB1)) also act via the cGMP-dependent protein kinase ERK 131 .…”

Section: Hif Inhibitors and Therapeutic Effectsmentioning

confidence: 93%

The role of hypoxia-inducible factors in metabolic diseases

2018

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Hypoxia-inducible factors (HIFs), a family of transcription factors activated by hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β), which serves as a heterodimerization partner of the HIFα subunits. HIFα subunits are stabilized from constitutive degradation by hypoxia largely through lowering the activity of the oxygen-dependent prolyl hydroxylases that hydroxylate HIFα, leading to their proteolysis. HIF1α and HIF2α are expressed in different tissues and regulate target genes involved in angiogenesis, cell proliferation and inflammation, and their expression is associated with different disease states. HIFs have been widely studied because of their involvement in cancer, and HIF2α-specific inhibitors are being investigated in clinical trials for the treatment of kidney cancer. Although cancer has been the major focus of research on HIF, evidence has emerged that this pathway has a major role in the control of metabolism and influences metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease. Notably increased HIF1α and HIF2α signalling in adipose tissue and small intestine, respectively, promotes metabolic diseases in diet-induced disease models. Inhibition of HIF1α and HIF2α decreases the adverse diet-induced metabolic phenotypes, suggesting that they could be drug targets for the treatment of metabolic diseases.

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Section: Hif Inhibitors and Therapeutic Effectsmentioning

confidence: 93%

The role of hypoxia-inducible factors in metabolic diseases

2018

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“…Sixty-five percent of all the patients had permi-cath. Fourteen patients (44% of patients with permi-cath), in addition to taking antibiotics were also hospitalized and had positive blood culture; this is while a study in Australia conducted during year 2012 reported an infection prevalence rate of 11%; 25% of this amount was related to blood infection due to permi-cath infection (13). Comparison of these statistics shows that the level of permi-cath infection in Iran is much higher than the international statistics.…”

Section: Defining the Problemmentioning

confidence: 96%

Practical Strategies for Decreasing and Controlling Permi-Cath Infection in Patients on Hemodialysis

Khojandi¹,

Dorri²,

Rahimipour-Anaraki³

et al. 2016

Crit Care Nurs J.

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Background: One of the methods for achieving vascular access in hemodialysis patients is using cuffed hemodialysis catheters (permicath), which has some risks such as infection. Staphylococcus is the most common microorganism that causes permi-cath infection, and has contaminated 90% of clinical staff. Objectives: This study aimed to determine some strategies to reduce the level of permi-cath infection in hemodialysis patients. Patients and Methods: This was an action research, conducted on 32 patients with permi-cath, 21 of whom had acquired this infection in the past six months. The subjects were selected through convenient sampling. The required data were collected by observations, interviews and using the data documented in the patients' medical files as well as a questionnaire. The etiological factors of permi-cath infection were investigated; the strategies were determined through staffs' participation and using a standard guideline. Economical strategies were administrated based on their priority and applicability. Results: Twenty-five (65 %) patients received antibiotics (vancomycin); this number decreased to one (4.6%) after the intervention. Fourteen (44 %) were hospitalized before the intervention; this also decreased to zero after the intervention. Therefore, there was a statistically significant difference between the number of patients taking antibiotics before and after the intervention. Conclusions: Action research is an appropriate method for changing and improving nurses' practice. Since staffs' viewpoints are considered in this method, it makes them accept the required changes more rapidly. In addition, the decisions that are made will be more stable.

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“…However, NO/cGMP might as well affect mitochondriogenesis [16,17] by cGKI-independent mechanisms i.e. via cross-talk through phosphodiesterases which may affect cAMP signaling [18,19] and at least one report has also questioned the presence of cGKI in murine adipocytes [20].…”

Section: Introductionmentioning

confidence: 96%