The article discusses the prospects of optimizing the technology of growing African catfish in high-tech industrial aquaculture. The goal was to determine the range of biologically active substances that can increase the productivity, organoleptic qualities of fish grown in recirculating aquaculture systems and optimize their living conditions. For this purpose, a complex of biologically active substances was tested, including probiotics, prebiotics, amino acids, and natural sorbents. It was introduced into feed and added to the water of fish tanks. Studies have shown that the developed complex of biologically active substances accelerates growth and development, guarantees the growth of fish biomass, reduces the level of bacterial pollution of the fish habitat, and normalizes hydrochemical parameters in the tanks. Improving the technology of fish farming in recirculating aquaculture systems (RAS) involves changing the ideology of feeding and keeping fish. The results of our studies show that, under conditions of artificial breeding in RAS, it is necessary to use cultures of living microorganisms probiotics that improve intestinal microbiocenosis in fish feeding and introduce them into the fish habitat. Probiotics should be used with prebiotics containing vitamin-amino acid complexes that stimulate the development of symbiotic microbiota. The use of natural sorbents plays an important role. The proposed set of ingredients increases the organoleptic qualities of fish. The studies were supported by the Russian Foundation for Basic Research with grant 18-016-00127.