Yeast cell templated porous hollow silica spheres for rapid hemostasis accompanied by antibacterial action

Abstract

Uncontrolled haemorrhage is the leading cause in nearly 91 % of pre-hospital deaths which were considered potentially survivable. Particularly severe trauma is susceptible to infection, which further affects the natural...

Recent Advances in Topical Hemostatic Materials

“…70 Shi et al prepared a yeast cell templated porous hollow silica spheres (Ag@HMSNs) with a porous structure, a negatively charged surface, and an enlarged specific surface area that determine their good hemostatic properties. 71 In addition, Ag@HMSNs have excellent bactericidal effects due to the presence of Ag.…”

“…Moreover, their tertiary stacked pores provided active sites for Ca 2+ to make full contact with coagulation factors to trigger the coagulation cascade reaction, and provided a stable environment for adsorption of plasma proteins to maintain activity for a longer time (Figure A) . Shi et al prepared a yeast cell templated porous hollow silica spheres (Ag@HMSNs) with a porous structure, a negatively charged surface, and an enlarged specific surface area that determine their good hemostatic properties . In addition, Ag@HMSNs have excellent bactericidal effects due to the presence of Ag.…”

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

“…It contains polar silanol groups on its surface, which can effectively promote blood coagulation [135]. The researchers used this structure to adsorb silver ions onto yeast to simulate diatomaceous earth cells and wrapped mesoporous silicon around the yeast to create silver-coated porous hollow silica spheres [136]. The resulting complex significantly improved blood hemostasis efficiency, reducing blood coagulation time by 290 s compared to the blank control group.…”

Clays and Wound Healing

“…In various societal accidents, numerous wounded people die due to massive hemorrhage and ineffective hemostasis [1][2][3]. The development of hemostatic materials with various active components and in different forms to achieve more efficient hemostasis in wound healing has continued to increase during long-term studies [4][5][6][7]. These commercial hemostatic materials include kaolinite, which is used in combat gauze from Z-Medica Corp. (Wallingford, CT, USA); zeolite, which is used in QuikClot from Z-Medica Corp.; montmorillonite, which is used in WoundStat from TraumaCure Inc. (Bethesda, MD, USA); mesoporous silicon and chitosan, which are used in TraumaStat from Ore-Medix Inc. (Salem, OR, USA); chitosan, which is used in Celox from MedTrade Inc. (Houston, TX, USA) and ChitoGauze Pro from HemCon Inc. (Portland, OR, USA); and cellulose, which is used in Traumastem from Bioster Inc. (Stillwater, MN, USA) [8].…”